A0A452RPG6 · A0A452RPG6_URSAM

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentalphav-beta3 integrin-IGF-1-IGF1R complex
Cellular Componentinsulin-like growth factor ternary complex
Molecular Functiongrowth factor activity
Molecular Functionhormone activity
Molecular Functioninsulin receptor binding
Molecular Functioninsulin-like growth factor receptor binding
Molecular Functionintegrin binding
Biological Processactivation of protein kinase B activity
Biological Processbone mineralization involved in bone maturation
Biological Processcell activation
Biological Processcell surface receptor signaling pathway via STAT
Biological Processcellular response to amyloid-beta
Biological Processinsulin-like growth factor receptor signaling pathway
Biological Processmuscle hypertrophy
Biological Processmyoblast differentiation
Biological Processmyoblast proliferation
Biological Processmyotube cell development
Biological Processnegative regulation of amyloid-beta formation
Biological Processnegative regulation of extrinsic apoptotic signaling pathway
Biological Processnegative regulation of interleukin-1 beta production
Biological Processnegative regulation of neuroinflammatory response
Biological Processnegative regulation of oocyte development
Biological Processnegative regulation of tumor necrosis factor production
Biological Processnegative regulation of vascular associated smooth muscle cell apoptotic process
Biological Processpositive regulation of activated T cell proliferation
Biological Processpositive regulation of calcineurin-NFAT signaling cascade
Biological Processpositive regulation of cell growth involved in cardiac muscle cell development
Biological Processpositive regulation of epithelial cell proliferation
Biological Processpositive regulation of ERK1 and ERK2 cascade
Biological Processpositive regulation of fibroblast proliferation
Biological Processpositive regulation of gene expression
Biological Processpositive regulation of glucose import
Biological Processpositive regulation of glycogen biosynthetic process
Biological Processpositive regulation of glycolytic process
Biological Processpositive regulation of glycoprotein biosynthetic process
Biological Processpositive regulation of insulin-like growth factor receptor signaling pathway
Biological Processpositive regulation of mitotic nuclear division
Biological Processpositive regulation of osteoblast differentiation
Biological Processpositive regulation of peptidyl-tyrosine phosphorylation
Biological Processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Processpositive regulation of protein secretion
Biological Processpositive regulation of Ras protein signal transduction
Biological Processpositive regulation of smooth muscle cell migration
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processpositive regulation of trophectodermal cell proliferation
Biological Processpositive regulation of vascular associated smooth muscle cell proliferation
Biological Processprotein stabilization
Biological Processproteoglycan biosynthetic process
Biological Processresponse to heat
Biological Processskeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
Biological Processwound healing

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Insulin-like growth factor I
  • Alternative names
    • Somatomedin

Gene names

    • Name
      IGF1

Organism names

Accessions

  • Primary accession
    A0A452RPG6

Proteomes

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-32
ChainPRO_501923991833-171Insulin-like growth factor I
Disulfide bond38↔80
Disulfide bond50↔93
Disulfide bond79↔84

Keywords

Interaction

Subunit

Forms a ternary complex with IGFR1 and ITGAV:ITGB3. Forms a ternary complex with IGFR1 and ITGA6:ITGB4.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain35-93Insulin-like
Region98-171Disordered
Compositional bias125-140Basic residues
Compositional bias154-171Basic and acidic residues

Sequence similarities

Belongs to the insulin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    171
  • Mass (Da)
    19,082
  • Last updated
    2019-05-08 v1
  • Checksum
    5774D266DA8975DA
MVTPTVKMHIMSSSHLFYLALCLLTFTSSATAGPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARSVRAQRHTDMPKAQKYRPPSTTKKTKSQRRRKGGPKKRPGGEQKVGTETSQQMKGKKKEQRRETGARN

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A452RPG7A0A452RPG7_URSAMIGF1137

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias125-140Basic residues
Compositional bias154-171Basic and acidic residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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