A0A452RBA4 · A0A452RBA4_URSAM

Function

Catalytic activity

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.
    EC:2.3.2.27 (UniProtKB | ENZYME | Rhea)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum
Cellular Componentnuclear inclusion body
Cellular Componentnucleoplasm
Cellular Componentprotein folding chaperone complex
Cellular Componentubiquitin ligase complex
Cellular ComponentZ disc
Molecular FunctionG protein-coupled receptor binding
Molecular FunctionHsp70 protein binding
Molecular FunctionHsp90 protein binding
Molecular Functionkinase binding
Molecular Functionmisfolded protein binding
Molecular Functionprotein homodimerization activity
Molecular FunctionR-SMAD binding
Molecular FunctionTPR domain binding
Molecular Functionubiquitin protein ligase binding
Molecular Functionubiquitin-ubiquitin ligase activity
Biological Processcellular response to misfolded protein
Biological Processendoplasmic reticulum unfolded protein response
Biological ProcessERAD pathway
Biological Processnegative regulation of smooth muscle cell apoptotic process
Biological Processnegative regulation of transforming growth factor beta receptor signaling pathway
Biological Processpositive regulation of chaperone-mediated protein complex assembly
Biological Processpositive regulation of ERAD pathway
Biological Processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Processpositive regulation of ubiquitin-protein transferase activity
Biological Processproteasome-mediated ubiquitin-dependent protein catabolic process
Biological Processprotein autoubiquitination
Biological Processprotein K63-linked ubiquitination
Biological Processprotein monoubiquitination
Biological Processprotein quality control for misfolded or incompletely synthesized proteins
Biological Processprotein stabilization
Biological Processregulation of glucocorticoid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    E3 ubiquitin-protein ligase CHIP
  • EC number
  • Alternative names
    • RING-type E3 ubiquitin transferase CHIP

Gene names

    • Name
      STUB1

Organism names

Accessions

  • Primary accession
    A0A452RBA4

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, repeat, coiled coil, domain.

Type
IDPosition(s)Description
Region1-30Disordered
Repeat60-93TPR
Repeat94-127TPR
Coiled coil100-127
Domain226-300U-box

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    303
  • Mass (Da)
    34,918
  • Last updated
    2019-05-08 v1
  • Checksum
    03DED0EC6AC2AC28
MKGKEEKEGGARLGAGGGSPEKSPSAQELKEQGNRLFVGRKYPEAAACYGRAITRNPLVAVYYTNRALCYLKMQQHEQALADCRRALELDGQSVKAHFFLGQCQLEMESYDEAIANLQRAYNLAKEQRLNFGDDIPSALRIAKKKRWNSIEERRIHQENELHSYLTRLIVAERERELEECQRNHEGDEDDGHIRAQQACIEAKHDKYLADMDELFSQVDEKRKKRDIPDYLCGKISFELMREPCITPSGITYDRKDIEEHLQRVGHFDPVTRSPLTQEQLIPNLAMKEVIDAFISENGWVEDY

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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