A0A452R393 · A0A452R393_URSAM
- ProteinProcollagen-lysine,2-oxoglutarate 5-dioxygenase 1
- GenePLOD1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids727 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils. Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.
Catalytic activity
- L-lysyl-[collagen] + 2-oxoglutarate + O2 = (5R)-5-hydroxy-L-lysyl-[collagen] + succinate + CO2
Cofactor
Protein has several cofactor binding sites:
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | rough endoplasmic reticulum membrane | |
Molecular Function | iron ion binding | |
Molecular Function | L-ascorbic acid binding | |
Molecular Function | procollagen-lysine 5-dioxygenase activity | |
Biological Process | epidermis development | |
Biological Process | peptidyl-lysine hydroxylation | |
Biological Process | response to hypoxia |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProcollagen-lysine,2-oxoglutarate 5-dioxygenase 1
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Ursidae > Ursus
Accessions
- Primary accessionA0A452R393
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Rough endoplasmic reticulum membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-18 | ||||
Chain | PRO_5019428614 | 19-727 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 | ||
Interaction
Subunit
Homodimer. Identified in a complex with P3H3 and P3H4.
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length727
- Mass (Da)83,534
- Last updated2019-05-08 v1
- Checksum80849D4182AD7C27
Keywords
- Technical term