A0A452QW85 · A0A452QW85_URSAM
- ProteinIntegrin beta
- GeneITGB1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids771 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameIntegrin beta
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Ursidae > Ursus
Accessions
- Primary accessionA0A452QW85
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 702-724 | Helical | ||||
Sequence: IIPIVAGVVAGIVLIGLALLLIW |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-22 | |||||
Sequence: MNLQLIFWIGLISSICCVFGQA | ||||||
Chain | PRO_5018993625 | 23-771 | Integrin beta | |||
Sequence: DENRCLKANAKSCGECIQAGPNCGWCTNSVSKIAQGLSIYSLVIYCGPILYLWEMLNMNFHLNQCLLNTYQLWEPQTFALKFKRAEDYPIDLYYLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFSYKNVLSLTDKGEVFNELVGKQRISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGQCHLENDVYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSANSSNVIQLIIDAYNSLSSEVILENSKLPEGVTINYKSYCKNGVNGTGENGRKCSNISIGDELFEILFRFKFITSNKCPNKDSETIKIKPLGFTEEVEVILQFICECECQSEGIPSSPKCHEGNGTFECGACRCNEGRVGRHCECSTDEVNSEDMDAYCRKENSSEICSNNGECVCGQCVCRKRDNTNEIYSGKFCECDNFNCDRSNGLICGGNGVCKCRVCECNPNYTGSACDCSLDTTSCLATNGQICNGRGVCECGACKCTDPKFQGPTCEMCQTCLGVCAEHKECVQCRAFNKGEKKDTCAQECSHFNITKVENRDKLPQPGQVDPLSHCKEKDVDDCWFYFTYSVNGNNEAIVHVVETPECPTGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVVNPKYEGK | ||||||
Disulfide bond | 35↔45 | |||||
Sequence: CGECIQAGPNC | ||||||
Disulfide bond | 176↔182 | |||||
Sequence: CTSEQNC | ||||||
Disulfide bond | 230↔270 | |||||
Sequence: CGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGQC | ||||||
Disulfide bond | 408↔664 | |||||
Sequence: CPNKDSETIKIKPLGFTEEVEVILQFICECECQSEGIPSSPKCHEGNGTFECGACRCNEGRVGRHCECSTDEVNSEDMDAYCRKENSSEICSNNGECVCGQCVCRKRDNTNEIYSGKFCECDNFNCDRSNGLICGGNGVCKCRVCECNPNYTGSACDCSLDTTSCLATNGQICNGRGVCECGACKCTDPKFQGPTCEMCQTCLGVCAEHKECVQCRAFNKGEKKDTCAQECSHFNITKVENRDKLPQPGQVDPLSHC | ||||||
Disulfide bond | 435↔439 | |||||
Sequence: CECEC | ||||||
Disulfide bond | 450↔462 | |||||
Sequence: CHEGNGTFECGAC | ||||||
Disulfide bond | 459↔498 | |||||
Sequence: CGACRCNEGRVGRHCECSTDEVNSEDMDAYCRKENSSEIC | ||||||
Disulfide bond | 464↔473 | |||||
Sequence: CNEGRVGRHC | ||||||
Disulfide bond | 475↔489 | |||||
Sequence: CSTDEVNSEDMDAYC | ||||||
Disulfide bond | 504↔509 | |||||
Sequence: CVCGQC | ||||||
Disulfide bond | 506↔541 | |||||
Sequence: CGQCVCRKRDNTNEIYSGKFCECDNFNCDRSNGLIC | ||||||
Disulfide bond | 511↔526 | |||||
Sequence: CRKRDNTNEIYSGKFC | ||||||
Disulfide bond | 528↔533 | |||||
Sequence: CDNFNC | ||||||
Disulfide bond | 547↔552 | |||||
Sequence: CKCRVC | ||||||
Disulfide bond | 549↔580 | |||||
Sequence: CRVCECNPNYTGSACDCSLDTTSCLATNGQIC | ||||||
Disulfide bond | 554↔563 | |||||
Sequence: CNPNYTGSAC | ||||||
Disulfide bond | 565↔572 | |||||
Sequence: CSLDTTSC | ||||||
Disulfide bond | 586↔591 | |||||
Sequence: CECGAC | ||||||
Disulfide bond | 588↔634 | |||||
Sequence: CGACKCTDPKFQGPTCEMCQTCLGVCAEHKECVQCRAFNKGEKKDTC | ||||||
Disulfide bond | 593↔603 | |||||
Sequence: CTDPKFQGPTC | ||||||
Disulfide bond | 606↔609 | |||||
Sequence: CQTC | ||||||
Disulfide bond | 613↔622 | |||||
Sequence: CAEHKECVQC | ||||||
Disulfide bond | 619↔696 | |||||
Sequence: CVQCRAFNKGEKKDTCAQECSHFNITKVENRDKLPQPGQVDPLSHCKEKDVDDCWFYFTYSVNGNNEAIVHVVETPEC | ||||||
Disulfide bond | 638↔672 | |||||
Sequence: CSHFNITKVENRDKLPQPGQVDPLSHCKEKDVDDC |
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 26-88 | PSI | ||||
Sequence: RCLKANAKSCGECIQAGPNCGWCTNSVSKIAQGLSIYSLVIYCGPILYLWEMLNMNFHLNQCL | ||||||
Domain | 34-437 | Integrin beta subunit VWA | ||||
Sequence: SCGECIQAGPNCGWCTNSVSKIAQGLSIYSLVIYCGPILYLWEMLNMNFHLNQCLLNTYQLWEPQTFALKFKRAEDYPIDLYYLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFSYKNVLSLTDKGEVFNELVGKQRISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGQCHLENDVYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSANSSNVIQLIIDAYNSLSSEVILENSKLPEGVTINYKSYCKNGVNGTGENGRKCSNISIGDELFEILFRFKFITSNKCPNKDSETIKIKPLGFTEEVEVILQFICEC | ||||||
Domain | 613-701 | Integrin beta subunit tail | ||||
Sequence: CAEHKECVQCRAFNKGEKKDTCAQECSHFNITKVENRDKLPQPGQVDPLSHCKEKDVDDCWFYFTYSVNGNNEAIVHVVETPECPTGPD | ||||||
Domain | 725-771 | Integrin beta subunit cytoplasmic | ||||
Sequence: KLLMIIHDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVVNPKYEGK |
Sequence similarities
Belongs to the integrin beta chain family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length771
- Mass (Da)85,582
- Last updated2019-05-08 v1
- ChecksumCFA21A9B983F7696
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A452QWE8 | A0A452QWE8_URSAM | ITGB1 | 770 | ||
A0A452QW99 | A0A452QW99_URSAM | ITGB1 | 753 | ||
A0A452QWC9 | A0A452QWC9_URSAM | ITGB1 | 759 | ||
A0A452QVU1 | A0A452QVU1_URSAM | ITGB1 | 769 |
Keywords
- Technical term