A0A452QTY7 · A0A452QTY7_URSAM
- ProteinReceptor-type tyrosine-protein phosphatase alpha
- GenePTPRA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids793 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 401 | substrate | |||
Active site | 433 | Phosphocysteine intermediate | |||
Binding site | 433-439 | substrate | |||
Binding site | 477 | substrate | |||
Active site | 723 | Phosphocysteine intermediate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | protein tyrosine phosphatase activity | |
Biological Process | protein dephosphorylation |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameReceptor-type tyrosine-protein phosphatase alpha
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Ursidae > Ursus
Accessions
- Primary accessionA0A452QTY7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 143-166 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-19 | ||||
Chain | PRO_5018824564 | 20-793 | Receptor-type tyrosine-protein phosphatase alpha | ||
Modified residue | 789 | Phosphotyrosine | |||
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 108-136 | Disordered | |||
Domain | 232-492 | Tyrosine-protein phosphatase | |||
Domain | 412-483 | Tyrosine specific protein phosphatases | |||
Domain | 524-782 | Tyrosine-protein phosphatase | |||
Domain | 698-773 | Tyrosine specific protein phosphatases | |||
Sequence similarities
Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length793
- Mass (Da)89,668
- Last updated2019-05-08 v1
- Checksum0EBBDCA090EBDDC8
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A452QTW6 | A0A452QTW6_URSAM | PTPRA | 802 |
Keywords
- Technical term