Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

A0A452QSN9 · A0A452QSN9_URSAM

Function

function

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentacrosomal membrane
Cellular Componentcaveolar macromolecular signaling complex
Cellular Componentfocal adhesion
Cellular ComponentGolgi membrane
Cellular Componentperinuclear region of cytoplasm
Cellular Componentsarcolemma
Cellular Componenttransport vesicle
Molecular Functionprotein heterodimerization activity
Molecular Functionprotein homodimerization activity
Molecular Functionprotein kinase binding
Molecular Functionprotein-macromolecule adaptor activity
Molecular Functionscaffold protein binding
Biological Processbasement membrane organization
Biological Processcaveola assembly
Biological Processendoplasmic reticulum organization
Biological Processendothelial cell proliferation
Biological Processinsulin receptor signaling pathway
Biological Processmitochondrion organization
Biological Processnegative regulation of endothelial cell proliferation
Biological Processnegative regulation of skeletal muscle cell proliferation
Biological Processnegative regulation of transforming growth factor beta receptor signaling pathway
Biological Processpositive regulation by host of viral process
Biological Processpositive regulation of dopamine receptor signaling pathway
Biological Processpositive regulation of endothelial cell proliferation
Biological Processpositive regulation of GTPase activity
Biological Processpositive regulation of MAPK cascade
Biological Processreceptor-mediated endocytosis of virus by host cell
Biological Processregulation of cytosolic calcium ion concentration
Biological Processregulation of mitotic nuclear division
Biological Processskeletal muscle cell proliferation
Biological Processskeletal muscle fiber development
Biological Processtransforming growth factor beta receptor signaling pathway
Biological Processvesicle docking
Biological Processvesicle fusion
Biological Processviral release from host cell

Names & Taxonomy

Protein names

  • Recommended name
    Caveolin

Gene names

    • Name
      CAV2

Organism names

Accessions

  • Primary accession
    A0A452QSN9

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein
Golgi apparatus membrane
; Peripheral membrane protein
Membrane, caveola
; Peripheral membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane87-114Helical

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the caveolin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    162
  • Mass (Da)
    18,092
  • Last updated
    2019-05-08 v1
  • MD5 Checksum
    B866EC8A94C97C41CD8629876E1C90D0
MGLETEKADVQLFMDDDAYSRHSGVDYADLDKFADSGSDRDPHRLNSHLKVGFEDVIAEPVSTHSFDKVWICSHALFEISKYVIYKFLTLFLAIPMAFAAGILFATLSCLHIWIIMPFVKTCLMVLPSVQTIWKSVTDVVIAPLCTSVGRSFSSVSLQLSHD

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help