A0A452QQU9 · A0A452QQU9_URSAM
- ProteinMitogen-activated protein kinase kinase kinase kinase
- GeneMAP4K3
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids768 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Cofactor
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 80 | Proton acceptor | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | MAP kinase kinase kinase kinase activity | |
Molecular Function | protein serine kinase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMitogen-activated protein kinase kinase kinase kinase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Ursidae > Ursus
Accessions
- Primary accessionA0A452QQU9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-207 | Protein kinase | ||||
Sequence: PGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVSLIFVFCFLKLQGLCYLHSKGKMHRDIKVYIISDFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV | ||||||
Compositional bias | 324-347 | Polar residues | ||||
Sequence: PQETHSTEDDNQGTIKRCPTSESP | ||||||
Region | 324-375 | Disordered | ||||
Sequence: PQETHSTEDDNQGTIKRCPTSESPAKPSQVPPRPPPPRLPPQKPIALGNGVS | ||||||
Compositional bias | 348-366 | Pro residues | ||||
Sequence: AKPSQVPPRPPPPRLPPQK | ||||||
Region | 390-416 | Disordered | ||||
Sequence: QQNEHRGTNPSRKEKKDVPKPISNGLP | ||||||
Domain | 435-752 | CNH | ||||
Sequence: PLKIHCATSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVSIPAHKLPDRILPRKFAVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRVFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESDSPQTSVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFRIESIVCLQDSVLAFWKHGMQGRSFRSNEVIFKNNFCLFITFRVVVLESRPTDNP |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length768
- Mass (Da)87,761
- Last updated2019-05-08 v1
- Checksum3076692E0E0EBEE7
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A452QR03 | A0A452QR03_URSAM | MAP4K3 | 810 | ||
A0A452QQY1 | A0A452QQY1_URSAM | MAP4K3 | 749 | ||
A0A452QQY6 | A0A452QQY6_URSAM | MAP4K3 | 763 | ||
A0A452QQV5 | A0A452QQV5_URSAM | MAP4K3 | 666 | ||
A0A452QR19 | A0A452QR19_URSAM | MAP4K3 | 761 | ||
A0A452QQN4 | A0A452QQN4_URSAM | MAP4K3 | 795 | ||
A0A452QR02 | A0A452QR02_URSAM | MAP4K3 | 763 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 324-347 | Polar residues | ||||
Sequence: PQETHSTEDDNQGTIKRCPTSESP | ||||||
Compositional bias | 348-366 | Pro residues | ||||
Sequence: AKPSQVPPRPPPPRLPPQK |
Keywords
- Technical term