A0A452QPY0 · A0A452QPY0_URSAM
- ProteinProtein kinase C
- GenePRKCB
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids639 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H+
Cofactor
Note: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domain.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 151 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 152 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 158 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 160 | a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) (UniProtKB | ChEBI) | |||
Binding site | 210 | a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) (UniProtKB | ChEBI) | |||
Binding site | 211 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 212 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 213 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 216 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 217 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 219 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 314-322 | ATP (UniProtKB | ChEBI) | |||
Binding site | 337 | ATP (UniProtKB | ChEBI) | |||
Active site | 432 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | diacylglycerol-dependent serine/threonine kinase activity | |
Molecular Function | zinc ion binding | |
Biological Process | adaptive immune response | |
Biological Process | protein phosphorylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein kinase C
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Ursidae > Ursus
Accessions
- Primary accessionA0A452QPY0
Proteomes
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 66-116 | Phorbol-ester/DAG-type | |||
Domain | 123-240 | C2 | |||
Domain | 308-566 | Protein kinase | |||
Domain | 567-637 | AGC-kinase C-terminal | |||
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length639
- Mass (Da)73,003
- Last updated2019-05-08 v1
- MD5 Checksum7715627F82B6349F6FE374840003E0CE
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A452QQC9 | A0A452QQC9_URSAM | PRKCB | 651 | ||
A0A452QQH0 | A0A452QQH0_URSAM | PRKCB | 536 | ||
A0A452QQA1 | A0A452QQA1_URSAM | PRKCB | 642 | ||
A0A452QQC6 | A0A452QQC6_URSAM | PRKCB | 619 | ||
A0A452QQ87 | A0A452QQ87_URSAM | PRKCB | 617 |
Keywords
- Technical term