Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

A0A452QPY0 · A0A452QPY0_URSAM

Function

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domain.

Features

Showing features for binding site, active site.

163950100150200250300350400450500550600
Type
IDPosition(s)Description
Binding site151Ca2+ 1 (UniProtKB | ChEBI)
Binding site152Ca2+ 1 (UniProtKB | ChEBI)
Binding site158Ca2+ 1 (UniProtKB | ChEBI)
Binding site160a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) (UniProtKB | ChEBI)
Binding site210a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) (UniProtKB | ChEBI)
Binding site211Ca2+ 1 (UniProtKB | ChEBI)
Binding site212Ca2+ 1 (UniProtKB | ChEBI)
Binding site213Ca2+ 1 (UniProtKB | ChEBI)
Binding site216Ca2+ 1 (UniProtKB | ChEBI)
Binding site217Ca2+ 1 (UniProtKB | ChEBI)
Binding site219Ca2+ 1 (UniProtKB | ChEBI)
Binding site314-322ATP (UniProtKB | ChEBI)
Binding site337ATP (UniProtKB | ChEBI)
Active site432Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular Functiondiacylglycerol-dependent serine/threonine kinase activity
Molecular Functionzinc ion binding
Biological Processadaptive immune response
Biological Processprotein phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein kinase C
  • EC number

Gene names

    • Name
      PRKCB

Organism names

Accessions

  • Primary accession
    A0A452QPY0

Proteomes

Subcellular Location

Cytoplasm
Membrane
; Peripheral membrane protein
Nucleus

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain66-116Phorbol-ester/DAG-type
Domain123-240C2
Domain308-566Protein kinase
Domain567-637AGC-kinase C-terminal

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    639
  • Mass (Da)
    73,003
  • Last updated
    2019-05-08 v1
  • MD5 Checksum
    7715627F82B6349F6FE374840003E0CE
IDIPGLMISSPHPSLPSLHFPSSLHPTLVFSYAVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIEREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVDGWFKLLSQEEGEYFNVPVPPEGSEGNEELRQKFEVSGLSFYVSGNWLSQPHFSDTNFSVKNHIDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGRNAENFDRFFTRHPPVLTPPDQEVIRNIDQSEFEGFSFVNSEFLKPEVKS

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A452QQC9A0A452QQC9_URSAMPRKCB651
A0A452QQH0A0A452QQH0_URSAMPRKCB536
A0A452QQA1A0A452QQA1_URSAMPRKCB642
A0A452QQC6A0A452QQC6_URSAMPRKCB619
A0A452QQ87A0A452QQ87_URSAMPRKCB617

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help