A0A452QNA3 · A0A452QNA3_URSAM

Function

Catalytic activity

Features

Showing features for binding site, active site.

126920406080100120140160180200220240260
Type
IDPosition(s)Description
Binding site10-17substrate
Active site11Tele-phosphohistidine intermediate
Binding site60substrate
Active site88Proton donor/acceptor
Binding site88-91substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentmitochondrial outer membrane
Cellular Componentnucleus
Molecular Functionfructose-2,6-bisphosphate 2-phosphatase activity
Biological Processcardiac muscle cell apoptotic process
Biological Processcellular response to cobalt ion
Biological Processcellular response to hypoxia
Biological ProcessDNA damage response
Biological Processfructose 2,6-bisphosphate metabolic process
Biological Processglucose catabolic process to lactate via pyruvate
Biological Processglycolytic process
Biological Processintestinal epithelial cell development
Biological Processmitophagy
Biological Processnegative regulation of glucose catabolic process to lactate via pyruvate
Biological Processnegative regulation of glycolytic process
Biological Processnegative regulation of mitophagy
Biological Processnegative regulation of programmed cell death
Biological Processnegative regulation of reactive oxygen species metabolic process
Biological Processpositive regulation of cardiac muscle cell apoptotic process
Biological Processpositive regulation of DNA repair
Biological Processpositive regulation of hexokinase activity
Biological Processpositive regulation of pentose-phosphate shunt
Biological Processreactive oxygen species metabolic process
Biological Processregulation of response to DNA damage checkpoint signaling
Biological Processresponse to gamma radiation
Biological Processresponse to ischemia
Biological Processresponse to xenobiotic stimulus

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fructose-2,6-bisphosphatase TIGAR
  • EC number
  • Alternative names
    • TP53-induced glycolysis and apoptosis regulator

Gene names

    • Name
      TIGAR

Organism names

Accessions

  • Primary accession
    A0A452QNA3

Proteomes

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the phosphoglycerate mutase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    269
  • Mass (Da)
    29,641
  • Last updated
    2019-05-08 v1
  • Checksum
    E16E7FE106D26BA7
MTRFALTVVRHGETRFNKEKIIQGQVDEPLSETGFKQAAAAGVFLNNVKFTHVFSSDLMRTKQTVHGILEKSKVCKDLTVKYDSRLRERKYGVAEGRALSELRAMAKAAGEECPMFTPPGGETLDQVKMRGKDFFDILCQLILQEAGQNEQFSQGAPSNCLETSLAEIFPLGKTCGSESNSDSGIPGLVASVLVVSHGAYMKSLFNYFLTDLKCSLPSTLNKSEFMSVSPNTGISLFIVNFEKGREVKPTIQCVCMYLQDHLNGGTETR

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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