A0A452QDP5 · A0A452QDP5_URSAM
- ProteinA-type potassium channel modulatory protein DPP6
- GeneDPP6
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids671 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | voltage-gated potassium channel complex | |
Molecular Function | potassium channel regulator activity | |
Molecular Function | serine-type peptidase activity | |
Biological Process | proteolysis | |
Biological Process | regulation of potassium ion transmembrane transport |
Names & Taxonomy
Protein names
- Recommended nameA-type potassium channel modulatory protein DPP6
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Ursidae > Ursus
Accessions
- Primary accessionA0A452QDP5
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type II membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 12-36 | Helical | ||||
Sequence: YSVLYFFFGGGSISVLISIILHYLV |
Keywords
- Cellular component
Interaction
Subunit
Homodimer (in vitro). Interacts with KCND2. Identified in a complex with KCND2 and KCNIP2. Forms an octameric complex composed of four DPP6 subunits bound to the KCND2 tetramer. Interacts with KCND3; this interaction modulates the channel gating kinetics namely channel activation and inactivation kinetics and rate of recovery from inactivation.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 82-416 | Dipeptidylpeptidase IV N-terminal | ||||
Sequence: RDPQSLDPPEVSNAKLQYAGWGPKGQQLIFIFENNIYYCAHVGKQAIRVVSTGKEGVIYNGLSDWLYEEEILKTHIAHWWSPDGTRLAYATINDSRVPIMELPTYTGSIYPTVKPYHYPKAGCENPSISLHVIGLNGPTHDLEMMPPDDPRMREYYITMVKWATSTKVAVNWLSRAQNVSILTLCDATTGVCTKKHEDESEAWLHRQNEEPVFSKDGRKFFFVRAIPQGGQGKFYHITVSSSQPNSSNDNIQSITSGDWDVTKILSYDEKRNKIYFLSTEDLPRRRQLYSASTVGTFNRQCLSCDLVENCTYFSASFSHSADFFLLKCEGPGVPT | ||||||
Domain | 498-548 | Peptidase S9 prolyl oligopeptidase catalytic | ||||
Sequence: VTWETVLVSSHGAVVVKCDGRGSGFQGTKLLHEVGRRLGSLEEKDQMEAGE | ||||||
Domain | 585-654 | Peptidase S9 prolyl oligopeptidase catalytic | ||||
Sequence: LEDQQFLIIHATADEKIHFQHTAELITQLIKGKANYSLQIYPDESHYFHSASLHQHLYRSIINFFVECFR |
Sequence similarities
Belongs to the peptidase S9B family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length671
- Mass (Da)76,097
- Last updated2019-05-08 v1
- ChecksumA2437134F9EA02B3
Computationally mapped potential isoform sequences
There are 9 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A452QCQ9 | A0A452QCQ9_URSAM | DPP6 | 779 | ||
A0A452QEA0 | A0A452QEA0_URSAM | DPP6 | 635 | ||
A0A452QE09 | A0A452QE09_URSAM | DPP6 | 693 | ||
A0A452QDK5 | A0A452QDK5_URSAM | DPP6 | 741 | ||
A0A452QDE7 | A0A452QDE7_URSAM | DPP6 | 747 | ||
A0A452QD67 | A0A452QD67_URSAM | DPP6 | 764 | ||
A0A452QCR0 | A0A452QCR0_URSAM | DPP6 | 721 | ||
A0A452QCE1 | A0A452QCE1_URSAM | DPP6 | 749 | ||
A0A452QCE9 | A0A452QCE9_URSAM | DPP6 | 751 |
Keywords
- Technical term