A0A452QB21 · A0A452QB21_URSAM

Function

function

Coreceptor for GDNF, a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. GDNF-binding leads to autophosphorylation and activation of the RET receptor.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentexternal side of plasma membrane
Cellular Componentreceptor complex
Molecular Functionsignaling receptor activity
Biological Processcell surface receptor protein tyrosine kinase signaling pathway
Biological Processnervous system development

Keywords

  • Molecular function

Names & Taxonomy

Protein names

  • Recommended name
    GDNF family receptor alpha-1
  • Short names
    GDNF receptor alpha-1

Gene names

    • Name
      GFRA1

Organism names

Accessions

  • Primary accession
    A0A452QB21

Proteomes

Subcellular Location

Cell membrane
; Lipid-anchor, GPI-anchor
Membrane
; Lipid-anchor, GPI-anchor

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-24
ChainPRO_501882557125-463GDNF family receptor alpha-1
Disulfide bond36↔42
Disulfide bond149↔209
Disulfide bond156↔162
Disulfide bond173↔187
Disulfide bond182↔228
Disulfide bond211↔216
Disulfide bond238↔308
Disulfide bond245↔251
Disulfide bond262↔280
Disulfide bond272↔332
Disulfide bond310↔320
Glycosylation342N-linked (GlcNAc...) asparagine
Glycosylation401N-linked (GlcNAc...) asparagine

Keywords

Interaction

Subunit

Interacts with GDNF ligand and RET: forms a 2:2:2 ternary complex composed of GDNF ligand, GFRA1 and RET receptor. Interacts with SORL1, either alone or in complex with GDNF. Interaction between SORL1 and GFRA1 leads to GFRA1 internalization, but not degradation.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain29-111GDNF/GAS1
Domain149-228GDNF/GAS1
Domain238-332GDNF/GAS1

Sequence similarities

Belongs to the GDNFR family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    463
  • Mass (Da)
    51,140
  • Last updated
    2019-05-08 v1
  • Checksum
    0E9C7687477C8F8A
MFLATLYFALPLLDVLLSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGKETNFSLTSGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSLQGNDLLEDSPYEPVNSRLSDIFRVVPFIPVEPVPKGNNCLDAAKACNLDDTCKKYRSAYITPCTTSMSNEVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCSYEEREKPNCLNLQDSCKTNYICRSRLADFFTNCQPESRSASSCLKENYADCLLAYSGLIGTVMTPNYIDSSSLSVAPWCDCSNSGNDMEECSKFLNFFKDNTCLKNAIQAFGNGSDVTVWQPALPVQTTTATTTTAFRAKNKPLGPAGSENEIPTHVLPPCANLQAQKLKSNVSGGTHLCLSDRDYEKNGLAGPSSHITTKSMAAPPSCGLSPLLVLVVTTLSTLFSLSLAETS

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A452QB15A0A452QB15_URSAMGFRA1469

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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