A0A452EI56 · A0A452EI56_CAPHI

  • Protein
    Tyrosine-protein phosphatase non-receptor type
  • Gene
    PTPN2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    5/5

Function

Catalytic activity

Features

Showing features for binding site, active site.

141750100150200250300350400
TypeIDPosition(s)Description
Binding site183substrate
Active site217Phosphocysteine intermediate
Binding site217-223substrate
Binding site261substrate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum
Cellular Componentendoplasmic reticulum-Golgi intermediate compartment
Cellular Componentendosome lumen
Cellular Componentnucleoplasm
Cellular Componentplasma membrane
Molecular Functionintegrin binding
Molecular Functionprotein tyrosine phosphatase activity
Molecular Functionreceptor tyrosine kinase binding
Molecular FunctionSTAT family protein binding
Molecular Functionsyntaxin binding
Biological ProcessB cell differentiation
Biological Processerythrocyte differentiation
Biological Processglucose homeostasis
Biological Processinsulin receptor recycling
Biological Processinsulin receptor signaling pathway
Biological Processnegative regulation of cell population proliferation
Biological Processnegative regulation of chemotaxis
Biological Processnegative regulation of epidermal growth factor receptor signaling pathway
Biological Processnegative regulation of ERK1 and ERK2 cascade
Biological Processnegative regulation of inflammatory response
Biological Processnegative regulation of insulin receptor signaling pathway
Biological Processnegative regulation of interleukin-2-mediated signaling pathway
Biological Processnegative regulation of interleukin-4-mediated signaling pathway
Biological Processnegative regulation of interleukin-6-mediated signaling pathway
Biological Processnegative regulation of lipid storage
Biological Processnegative regulation of macrophage colony-stimulating factor signaling pathway
Biological Processnegative regulation of macrophage differentiation
Biological Processnegative regulation of platelet-derived growth factor receptor-beta signaling pathway
Biological Processnegative regulation of positive thymic T cell selection
Biological Processnegative regulation of T cell receptor signaling pathway
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processnegative regulation of tumor necrosis factor-mediated signaling pathway
Biological Processnegative regulation of type I interferon-mediated signaling pathway
Biological Processnegative regulation of type II interferon-mediated signaling pathway
Biological Processnegative regulation of tyrosine phosphorylation of STAT protein
Biological Processpositive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
Biological Processpositive regulation of gluconeogenesis
Biological Processpositive regulation of PERK-mediated unfolded protein response
Biological Processregulation of hepatocyte growth factor receptor signaling pathway
Biological ProcessT cell differentiation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tyrosine-protein phosphatase non-receptor type
  • EC number

Gene names

    • Name
      PTPN2

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Caprinae > Capra

Accessions

  • Primary accession
    A0A452EI56

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane389-410Helical

Keywords

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-276Tyrosine-protein phosphatase
Domain191-267Tyrosine specific protein phosphatases

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    417
  • Mass (Da)
    48,498
  • Last updated
    2019-05-08 v1
  • Checksum
    2F32DA461AE145CC
MSAAIEREFEELDAQNRWQQLYLEIRSESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTGCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTKDDREMLFKETGFSVKFLSEDVKSYYTVHLLQLGNTRTGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPEHGPAVIHCSAGIGRSGTFSLVDSCLVLIEKGDNINIKQLLLNMRKYRMGLIQTPDQLRFSYMTIIEGAKFIKGDSSIQKRWKELSKEDVCPVFDHSPTKIMTEKYNGNRIGLEEEKLTGDRYSGLSSKTQEALEESSESALRKRLREDRKASTAQKVQQMKQRLSETERKRKRWLYWQPILTKMGFVSVILVGAFVGWTLFLHLTDTL

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A452EI40A0A452EI40_CAPHIPTPN2388
A0A452EI42A0A452EI42_CAPHIPTPN2401
A0A452EI47A0A452EI47_CAPHIPTPN2398

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LWLT01000023
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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