A0A448YF77 · A0A448YF77_BRENA
- ProteinATP-dependent RNA helicase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids787 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
ATP-dependent RNA helicase required for ribosome biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal complexes. Required for pre-rRNA cleavage at site A2.
RNA helicase.
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleolus | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | RNA binding | |
Molecular Function | RNA helicase activity | |
Biological Process | rRNA processing |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent RNA helicase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Pichiaceae > Brettanomyces
Accessions
- Primary accessionA0A448YF77
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Interacts with the U3 and U14 snoRNAs. Associates with pre-ribosomal complexes.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, motif, compositional bias, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 43-71 | DEAD-box RNA helicase Q | |||
Motif | 43-71 | Q motif | |||
Domain | 74-248 | Helicase ATP-binding | |||
Domain | 274-433 | Helicase C-terminal | |||
Compositional bias | 635-698 | Basic and acidic residues | |||
Region | 635-787 | Disordered | |||
Compositional bias | 714-734 | Acidic residues | |||
Compositional bias | 735-754 | Basic and acidic residues | |||
Domain
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence similarities
Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length787
- Mass (Da)89,479
- Last updated2019-05-08 v1
- ChecksumF41411EC3BCA00C8
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 635-698 | Basic and acidic residues | |||
Compositional bias | 714-734 | Acidic residues | |||
Compositional bias | 735-754 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CAACVR010000001 EMBL· GenBank· DDBJ | VEU19561.1 EMBL· GenBank· DDBJ | Genomic DNA |