A0A447X8G7 · A0A447X8G7_ECOLX

  • Protein
    NAD(P)H-hydrate epimerase
  • Gene
    nnr
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

K+ (UniProtKB | Rhea| CHEBI:29103 )

Note: Binds 1 potassium ion per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site66-70(6S)-NADPHX (UniProtKB | ChEBI)
Binding site67K+ (UniProtKB | ChEBI)
Binding site130K+ (UniProtKB | ChEBI)
Binding site134-140(6S)-NADPHX (UniProtKB | ChEBI)
Binding site163(6S)-NADPHX (UniProtKB | ChEBI)
Binding site166K+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionADP-dependent NAD(P)H-hydrate dehydratase activity
Molecular FunctionATP binding
Molecular Functionkinase activity
Molecular Functionmetal ion binding
Molecular FunctionNAD(P)HX epimerase activity
Biological Processmetabolite repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD(P)H-hydrate epimerase
  • EC number
  • Alternative names
    • NAD(P)HX epimerase

Gene names

    • Name
      nnr
    • Synonyms
      nnrE
    • ORF names
      NCTC9044_02648

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NCTC9044
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia

Accessions

  • Primary accession
    A0A447X8G7

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain18-220YjeF N-terminal
Domain229-351YjeF C-terminal

Sequence similarities

Belongs to the NnrE/AIBP family.
In the C-terminal section; belongs to the NnrD/CARKD family.
In the N-terminal section; belongs to the NnrE/AIBP family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    351
  • Mass (Da)
    37,830
  • Last updated
    2019-05-08 v1
  • MD5 Checksum
    2163F03EAE0BD9FC67BFEB651FE06B3F
MKKNPVSIPHTVWHADDIRRGEREAADALGLTLYELMLRAGEAAFQVCRTAYPNARHWLVLCGHGNNGGDGYVVARLAKAVGIEVTLLAQESDKPLPEEAALAREAWLNAGGEIHASNTVWPESVDLIVDALLGTGLQQAPRESISQLIDHANSHPAPIVAVDIPSGLLAETGATPGAVINADHTITFIALKPGLLTGKARDVTGQLHFDSLGLDSWLAGQETKIQRFSAEQLPHWLKPRRPTSHKGDHGRLVIIGGDHGTAGAIRMTGEAALRAGAGLVRVLTRSENIAPLLTARPELMVHELTMDFLTESLEWADVVVIGPGLGQQEWGKKALQKVENFRNRCCGMPMH

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LR134238
EMBL· GenBank· DDBJ
VED10970.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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