A0A447SSE2 · A0A447SSE2_AVIVO

Function

function

Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion.

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4.
Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site59Zn2+ (UniProtKB | ChEBI); catalytic
Active site61Proton donor
Binding site84Zn2+ (UniProtKB | ChEBI); catalytic
Binding site93Zn2+ (UniProtKB | ChEBI); catalytic
Binding site163NADP+ (UniProtKB | ChEBI)
Binding site177substrate
Binding site179NADP+ (UniProtKB | ChEBI)
Binding site193substrate
Binding site205NADP+ (UniProtKB | ChEBI)
Binding site209NADP+ (UniProtKB | ChEBI)
Binding site213substrate
Binding site216substrate
Binding site243NADP+ (UniProtKB | ChEBI)
Binding site307substrate
Binding site309-315NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function5-amino-6-(5-phosphoribosylamino)uracil reductase activity
Molecular Functiondiaminohydroxyphosphoribosylaminopyrimidine deaminase activity
Molecular FunctionNADP binding
Molecular Functionzinc ion binding
Biological Processriboflavin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Riboflavin biosynthesis protein RibD

Including 2 domains:

  • Recommended name
    Diaminohydroxyphosphoribosylaminopyrimidine deaminase
  • EC number
  • Short names
    DRAP deaminase
  • Alternative names
    • Riboflavin-specific deaminase
  • Recommended name
    5-amino-6-(5-phosphoribosylamino)uracil reductase
  • EC number
  • Alternative names
    • HTP reductase

Gene names

    • Name
      ribD
    • ORF names
      NCTC3438_01706

Organism names

Accessions

  • Primary accession
    A0A447SSE2

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain10-132CMP/dCMP-type deaminase

Sequence similarities

In the C-terminal section; belongs to the HTP reductase family.
In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    376
  • Mass (Da)
    41,136
  • Last updated
    2019-05-08 v1
  • Checksum
    C56DBC78C9D16EE5
MQQNAQQFTQQDQQFMQMALDLASQGRFTTTPNPSVGCVLVKDGKVIGKGFHLKAGQPHAEVMALREAGENARGATAYVTLEPCSHFGRTPPCAKGLIEAGVAKVIAAMTDPNPQVAGRGLKILEQAGVQTAVGLLAEKAELLNQGFLKRMRSNRPFVQLKMAMSIDGRTAMASGESKWITGEQARQDVQQYRAAASAILSTSQTVLMDNPMLNVRWEQLPLSVQQQYPDTELCQPGRIILDSQHRVTPEYQLFQQPTPVWLVSSGARDMQGFPDFCQAIQIEKSADFFTALLTELAERQINSLWIEAGAQLAGALIEAKLVDELIVYIAPKLLGDAGKGLCHLPHLHKLADAPLWQLQSATPVGEDLKLIYQPKN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LR134167
EMBL· GenBank· DDBJ
VEB24798.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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