A0A445N3F0 · A0A445N3F0_9BACT

Function

function

Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.
One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site, site.

Type
IDPosition(s)Description
Binding site119(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Binding site123-125(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Site227Plays an important role in substrate specificity

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncobalt ion binding
Molecular Functionglycine hydroxymethyltransferase activity
Molecular Functionmethyltransferase activity
Molecular Functionpyridoxal phosphate binding
Molecular Functionserine binding
Molecular Functionzinc ion binding
Biological Processfolic acid metabolic process
Biological Processglycine biosynthetic process from serine
Biological ProcessL-serine catabolic process
Biological Processmethylation
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine hydroxymethyltransferase
  • EC number
  • Short names
    SHMT
    ; Serine methylase

Gene names

    • Name
      glyA
    • ORF names
      PITCH_A850014

Organism names

  • Taxonomic identifier
  • Strain
    • TRIP AH-1
  • Taxonomic lineage
    Bacteria > Thermodesulfobacteriota > Desulfobacteria > Desulfobacterales > Desulfobacteriaceae > Desulfobacterium > environmental samples

Accessions

  • Primary accession
    A0A445N3F0

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue228N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-382Serine hydroxymethyltransferase-like

Sequence similarities

Belongs to the SHMT family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    421
  • Mass (Da)
    46,040
  • Last updated
    2019-05-08 v1
  • MD5 Checksum
    30AD4915FC8AEBC11BE70EE3F7E9E89F
MDERRLREIDPEVYAAIRSEINREKNNLLMIASENYASLAVIEAQANVMTNKYAEGYPGARYYGGCEFVDVVERLAIERAKKLFGAEHVNVQPHSGSQANMAVYLSFFKPGDVIMGMDLSHGGHLTHGSPASFSGTMFKSVSYGLNPKSQRIDYDQIRDVAKKHSPRVIVAGASAYPRIIDFKLFKEIAEENNAYLMADMAHIAGLVATGLHPSPVGVADFVTTTTHKTLRGPRGGLILAQQKYAEKLDKALFPGIQGGPLMHIIAAKAVSFQEALRAEFSIYQRQVVDNARVLAEELLNYGFDLVTGGTDNHLILVDLTKRGITGLDAERALGLAGIVANKNAVPFDKRGPKTTSGLRLGTPALTTRGMKENEMSIVAGLIREALEHPESETVLQDISRSVAELCSLFPVYENLDRGHDL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
OJIN01000231
EMBL· GenBank· DDBJ
SPD76211.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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