A0A443ZRP1 · A0A443ZRP1_9PSED

Function

function

This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.
    EC:3.4.23.36 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; lipoprotein biosynthesis (signal peptide cleavage).

Features

Showing features for active site.

117120406080100120140160
TypeIDPosition(s)Description
Active site126
Active site145

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionaspartic-type endopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lipoprotein signal peptidase
  • EC number
  • Alternative names
    • Prolipoprotein signal peptidase
    • Signal peptidase II
      (SPase II
      )

Gene names

    • Name
      lspA
    • ORF names
      DM813_12900

Organism names

  • Taxonomic identifier
  • Strain
    • xwS2
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    A0A443ZRP1

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane73-91Helical
Transmembrane98-116Helical
Transmembrane136-157Helical

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the peptidase A8 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    171
  • Mass (Da)
    19,059
  • Last updated
    2019-05-08 v1
  • Checksum
    6373E7C9FBBF136B
MPNPAAGRFGRLGWLWLSLLVLVLDQASKVYFEGALSLYQQIVVIPDYFSWTLAYNTGAAFSFLADSSGWQRWLFALIALVVSAVLVVWLKRLGRNETWLAVALALVLGGALGNLYDRIVLGHVVDFILVHWQNRWYFPAFNLADSAITVGAVMLALDMFKSKKSGEPVHD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QJRG01000044
EMBL· GenBank· DDBJ
RWU22091.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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