A0A443ZEC5 · A0A443ZEC5_9PSED

Function

function

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

Miscellaneous

The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site60Cysteine sulfenic acid (-SOH) intermediate

GO annotations

AspectTerm
Molecular Functionthioredoxin peroxidase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Thiol peroxidase
  • EC number
  • Short names
    Tpx
  • Alternative names
    • Peroxiredoxin tpx
      (Prx
      )
    • Thioredoxin peroxidase
    • Thioredoxin-dependent peroxiredoxin

Gene names

    • Name
      tpx
    • ORF names
      DM813_27155

Organism names

  • Taxonomic identifier
  • Strain
    • xwS2
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    A0A443ZEC5

Proteomes

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond60↔94Redox-active

Keywords

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain18-166Thioredoxin

Sequence similarities

Belongs to the peroxiredoxin family. Tpx subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    166
  • Mass (Da)
    17,305
  • Last updated
    2019-05-08 v1
  • Checksum
    8D231A9BF857B0B2
MAQVTLKGNPVQVKGELPKVGAKAPAFSLVGAGLADVTLASLAGKRKVLNIFPSVDTPTCATSVRTFNKKAGELNNTVVLCISADLPFAQARFCGAEGLENVQNLSTLRGREFIENYGVAIADGPLAGLTARAVVVLDENDTVLHSELVGEIADEPNYDAALAVLK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QJRG01000050
EMBL· GenBank· DDBJ
RWU17044.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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