A0A443W9Z2 · A0A443W9Z2_9ENTR
- ProteinPeriplasmic trehalase
- GenetreA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids582 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system.
Catalytic activity
- alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 156 | substrate | ||||
Sequence: R | ||||||
Binding site | 163-164 | substrate | ||||
Sequence: WD | ||||||
Binding site | 200 | substrate | ||||
Sequence: N | ||||||
Binding site | 209-211 | substrate | ||||
Sequence: RSQ | ||||||
Binding site | 281-283 | substrate | ||||
Sequence: RPE | ||||||
Binding site | 314 | substrate | ||||
Sequence: G | ||||||
Active site | 316 | Proton donor/acceptor | ||||
Sequence: D | ||||||
Active site | 500 | Proton donor/acceptor | ||||
Sequence: E | ||||||
Binding site | 515 | substrate | ||||
Sequence: E |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | periplasmic space | |
Molecular Function | alpha,alpha-trehalase activity | |
Biological Process | cellular hyperosmotic response | |
Biological Process | trehalose catabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePeriplasmic trehalase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Klebsiella/Raoultella group > Klebsiella
Accessions
- Primary accessionA0A443W9Z2
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-34 | |||||
Sequence: MTSPVSRRPATLPFALRLALGGAFVALATLTAQA | ||||||
Chain | PRO_5019595384 | 35-582 | Periplasmic trehalase | |||
Sequence: EETRPTPQSPDILLGPLFNDVQSAKLFSDQKTFADAIPNGDPLMILADYRMQKSQTSFDLRHFVELNFTLPRENDQYVPPKGQTLRQHINGLWPVLTRSTVDVEKWDSLLPLPKPYVVPGGRFREVYYWDSYFTMLGLAESGHWDKIEDMVTNFAAEIDAWGHIPNGNRTYYLSRSQPPFFPFMVELLATHEGDETLKKWLPQMEKEYQYWMDGAEALEPGSASKRVVRMADGALLNRYWDDNDTPRPESWLDDVTTAKNNPNRPATEIYRDLRSAAASGWDFSSRWMDNPQQLGTIRTTSIVPVDLNSLMFHMEKTIARASKAAGDSAKSAQYDALANARQKALEKYLWNDKEGWYADYDLKSHKVRNQLTAAALFPLYVNAASSERAAKVAAATEARLLKPGGLTTTTVNSGQQWDAPNGWAPLQWVAAEGLQKYGQQKIAMEVSWRFLSNVQHTYNSEQKLVEKYDVSSTGTGGGGGEYPLQDGFGWTNGVTLKMLDLVCPKEKPCDSVPTARPAANDDNGKAADVSAQPAAQQPAAVEEKKVAP |
Interaction
Subunit
Monomer.
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 541-582 | Disordered | ||||
Sequence: KPCDSVPTARPAANDDNGKAADVSAQPAAQQPAAVEEKKVAP |
Sequence similarities
Belongs to the glycosyl hydrolase 37 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length582
- Mass (Da)64,809
- Last updated2019-05-08 v1
- Checksum1E9E35204F6D25FB