A0A443VL50 · A0A443VL50_RAOPL
- ProteinGlycine dehydrogenase (decarboxylating)
- GenegcvP
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids957 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
Catalytic activity
- N6-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H+ = N6-[(R)-S8-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | glycine cleavage complex | |
Molecular Function | glycine binding | |
Molecular Function | glycine dehydrogenase (decarboxylating) activity | |
Molecular Function | pyridoxal phosphate binding | |
Biological Process | glycine decarboxylation via glycine cleavage system |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlycine dehydrogenase (decarboxylating)
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Klebsiella/Raoultella group > Raoultella
Accessions
- Primary accessionA0A443VL50
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Modified residue | 708 | N6-(pyridoxal phosphate)lysine | ||||
Sequence: K |
Interaction
Subunit
The glycine cleavage system is composed of four proteins: P, T, L and H.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 16-438 | Glycine cleavage system P-protein N-terminal | ||||
Sequence: ERHIGPDAQQQQEMLNTVGADSLNALIGQIVPQDIQLATPPQVGDATTEFAALAELKAIAGRNKRFKSYIGMGYTAVQLPPVIQRNMLENPGWYTAYTPYQPEVSQGRLESLLNFQQVTLDLTGLDIASASLLDEATAGAEAMAMAKRVSKLKNANRFFVAADVHPQTLDVVRTRAATFGFDVIVDEAEKALDHQDVFGVLLQQVGTTGEIHDYSKLIAELKARKVVVSVAADFMALVLLTAPGKQGADIVFGSAQRFGVPMGYGGPHAAFFAAKDEFKRSMPGRIIGVSKDAAGNTALRMAMQTREQHIRREKANSNICTSQVLLANIASLYAVFHGPEGLKSIASRIHRLTDILADGLQKKGLKLRHAHYFDTLCVEVVDKAAVLARAEALEINLRSDIHNAVGITLDEATTREDVLNLFR | ||||||
Domain | 460-739 | Glycine cleavage system P-protein N-terminal | ||||
Sequence: SRSIPESMLRNDAILTHPVFNRYHSETEMMRYMHSLERKDLALNQAMIPLGSCTMKLNAAAEMIPITWPEFAELHPFCPAEQAEGYHQMIAQLSDWLVKLTGYDAVCMQPNSGAQGEYAGLLAIRHYHESRNEGHRDICLIPSSAHGTNPASAQMAGMQVVVVACDKNGNIDLADLRLKAEQAGENLSCIMVTYPSTHGVYEETIREVCEIVHQFGGQVYLDGANMNAQVGITSPGFIGADVSHLNLHKTFCIPHGGGGPGMGPIGVKAHLAPFVPGHSV | ||||||
Domain | 781-902 | Glycine dehydrogenase C-terminal | ||||
Sequence: ASQVAILNANYIATRLKEAFPVLYTGRDGRVAHECILDIRPLKEETGISELDIAKRLIDFGFHAPTMSFPVAGTLMVEPTESESKVELDRFIDAMLAIRSEIDRVQAGEWPLEDNPLVNAPH |
Sequence similarities
Belongs to the GcvP family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length957
- Mass (Da)104,563
- Last updated2019-05-08 v1
- Checksum5FC849108F02A19F