A0A443VL50 · A0A443VL50_RAOPL

Function

function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentglycine cleavage complex
Molecular Functionglycine binding
Molecular Functionglycine dehydrogenase (decarboxylating) activity
Molecular Functionpyridoxal phosphate binding
Biological Processglycine decarboxylation via glycine cleavage system

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glycine dehydrogenase (decarboxylating)
  • EC number
  • Alternative names
    • Glycine cleavage system P-protein
    • Glycine decarboxylase
    • Glycine dehydrogenase (aminomethyl-transferring)

Gene names

    • Name
      gcvP
    • ORF names
      DN603_15800

Organism names

Accessions

  • Primary accession
    A0A443VL50

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue708N6-(pyridoxal phosphate)lysine

Interaction

Subunit

The glycine cleavage system is composed of four proteins: P, T, L and H.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain16-438Glycine cleavage system P-protein N-terminal
Domain460-739Glycine cleavage system P-protein N-terminal
Domain781-902Glycine dehydrogenase C-terminal

Sequence similarities

Belongs to the GcvP family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    957
  • Mass (Da)
    104,563
  • Last updated
    2019-05-08 v1
  • Checksum
    5FC849108F02A19F
MTQTLGQLENRGAFIERHIGPDAQQQQEMLNTVGADSLNALIGQIVPQDIQLATPPQVGDATTEFAALAELKAIAGRNKRFKSYIGMGYTAVQLPPVIQRNMLENPGWYTAYTPYQPEVSQGRLESLLNFQQVTLDLTGLDIASASLLDEATAGAEAMAMAKRVSKLKNANRFFVAADVHPQTLDVVRTRAATFGFDVIVDEAEKALDHQDVFGVLLQQVGTTGEIHDYSKLIAELKARKVVVSVAADFMALVLLTAPGKQGADIVFGSAQRFGVPMGYGGPHAAFFAAKDEFKRSMPGRIIGVSKDAAGNTALRMAMQTREQHIRREKANSNICTSQVLLANIASLYAVFHGPEGLKSIASRIHRLTDILADGLQKKGLKLRHAHYFDTLCVEVVDKAAVLARAEALEINLRSDIHNAVGITLDEATTREDVLNLFRAIIGDDHGLDIDTLDKDVALDSRSIPESMLRNDAILTHPVFNRYHSETEMMRYMHSLERKDLALNQAMIPLGSCTMKLNAAAEMIPITWPEFAELHPFCPAEQAEGYHQMIAQLSDWLVKLTGYDAVCMQPNSGAQGEYAGLLAIRHYHESRNEGHRDICLIPSSAHGTNPASAQMAGMQVVVVACDKNGNIDLADLRLKAEQAGENLSCIMVTYPSTHGVYEETIREVCEIVHQFGGQVYLDGANMNAQVGITSPGFIGADVSHLNLHKTFCIPHGGGGPGMGPIGVKAHLAPFVPGHSVVQIEGMLTRQGAVSAAPFGSASILPISWMYIRMMGAEGLKQASQVAILNANYIATRLKEAFPVLYTGRDGRVAHECILDIRPLKEETGISELDIAKRLIDFGFHAPTMSFPVAGTLMVEPTESESKVELDRFIDAMLAIRSEIDRVQAGEWPLEDNPLVNAPHTQGELVAEWNHPYTRELAVFPAGLANKYWPTVKRLDDVYGDRNLFCSCVPMSEYQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QKOX01000015
EMBL· GenBank· DDBJ
RWT21894.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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