A0A438N5I2 · A0A438N5I2_EXOME
- ProteinProtein N-terminal and lysine N-methyltransferase EFM7
- GeneEFM7
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids590 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 59 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 86-88 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 108 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 140 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 164 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | hydrolase activity, hydrolyzing O-glycosyl compounds | |
Molecular Function | N-terminal protein N-methyltransferase activity | |
Molecular Function | protein-lysine N-methyltransferase activity | |
Biological Process | carbohydrate metabolic process | |
Biological Process | N-terminal peptidyl-glycine methylation | |
Biological Process | peptidyl-lysine dimethylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein N-terminal and lysine N-methyltransferase EFM7
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Chaetothyriomycetidae > Chaetothyriales > Herpotrichiellaceae > Exophiala
Accessions
- Primary accessionA0A438N5I2
Proteomes
Organism-specific databases
Subcellular Location
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-25 | Disordered | |||
Region | 269-331 | Disordered | |||
Compositional bias | 276-312 | Polar residues | |||
Domain | 352-587 | GH16 | |||
Region | 488-509 | Disordered | |||
Sequence similarities
Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length590
- Mass (Da)65,713
- Last updated2019-05-08 v1
- MD5 Checksum31E31F21059D4FBCE0108169ED5DB2FB
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 276-312 | Polar residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
NAJM01000020 EMBL· GenBank· DDBJ | RVX70979.1 EMBL· GenBank· DDBJ | Genomic DNA |