A0A437DIF2 · A0A437DIF2_ORYJA
- ProteinTyrosine-protein kinase receptor
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids815 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
Features
Showing features for site, binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 506 | Interaction with SHC1 | |||
Binding site | 534-542 | ATP (UniProtKB | ChEBI) | |||
Binding site | 562 | ATP (UniProtKB | ChEBI) | |||
Active site | 669 | Proton acceptor | |||
Site | 810 | Interaction with PLCG1 | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | axon | |
Cellular Component | plasma membrane | |
Cellular Component | receptor complex | |
Molecular Function | ATP binding | |
Molecular Function | neurotrophin binding | |
Molecular Function | neurotrophin receptor activity | |
Molecular Function | transmembrane receptor protein tyrosine kinase activity | |
Biological Process | cell differentiation | |
Biological Process | cell surface receptor protein tyrosine kinase signaling pathway | |
Biological Process | cellular response to nerve growth factor stimulus | |
Biological Process | nervous system development | |
Biological Process | positive regulation of kinase activity | |
Biological Process | positive regulation of neuron projection development | |
Biological Process | protein phosphorylation | |
Biological Process | regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTyrosine-protein kinase receptor
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Atherinomorphae > Beloniformes > Adrianichthyidae > Oryziinae > Oryzias
Accessions
- Primary accessionA0A437DIF2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 420-443 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-28 | ||||
Chain | PRO_5019323173 | 29-815 | Tyrosine-protein kinase receptor | ||
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 207-299 | Ig-like | |||
Domain | 528-802 | Protein kinase | |||
Sequence similarities
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length815
- Mass (Da)92,530
- Last updated2019-05-08 v1
- ChecksumF125BD3C3B83A24D
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CM012439 EMBL· GenBank· DDBJ | RVE74823.1 EMBL· GenBank· DDBJ | Genomic DNA |