A0A437D4S3 · A0A437D4S3_ORYJA

Function

function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Catalytic activity

Features

Showing features for binding site, active site, site.

110551002003004005006007008009001,000
Type
IDPosition(s)Description
Binding site638Zn2+ (UniProtKB | ChEBI)
Binding site640Zn2+ (UniProtKB | ChEBI)
Binding site646Zn2+ (UniProtKB | ChEBI)
Binding site723Zn2+ (UniProtKB | ChEBI)
Active site775
Site948Contributes to catalysis

GO annotations

AspectTerm
Cellular Componenthistone deacetylase complex
Molecular Functionhistone deacetylase activity
Molecular Functionmetal ion binding
Biological Processnegative regulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histone deacetylase
  • EC number

Gene names

    • ORF names
      OJAV_G00061740

Organism names

  • Taxonomic identifier
  • Strain
    • RS831
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Atherinomorphae > Beloniformes > Adrianichthyidae > Oryziinae > Oryzias

Accessions

  • Primary accession
    A0A437D4S3

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-19
ChainPRO_501897413620-1055Histone deacetylase

Family & Domains

Features

Showing features for compositional bias, region, domain.

Type
IDPosition(s)Description
Compositional bias161-181Basic and acidic residues
Region161-191Disordered
Region207-314Disordered
Compositional bias235-251Polar residues
Compositional bias292-314Polar residues
Region488-523Disordered
Compositional bias491-507Basic and acidic residues
Region582-617Disordered
Compositional bias590-607Polar residues
Domain646-963Histone deacetylase

Sequence similarities

Belongs to the histone deacetylase family. HD type 2 subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,055
  • Mass (Da)
    114,416
  • Last updated
    2019-05-08 v1
  • Checksum
    658454F121E31FF8
MLHFLTAGWLGGLAVEGRGLTVAVTPSQFLLSRSGSTDSRGAPVTSRSRFPPPSGLFRTAARLDYPAAFGASLGRHPRWSQAPWELRENRRDAVLHTVTDSSLAVLQTLSALLLMDLRVGERGMRPGSDTALLTRLHPPLLLTTSFSQHQLHQQIRFNMEQRRQEQERHEKQQELQQLRHKDKSQQSAVASSLVKQKLQEVILKKQKQAALERTNPPHPVPYRKLGPDPSAAAQPLVSPPSQSSPERTQLRRAASEPNLKVKNKLKKHLNTRKSPLTRKESAPPTVKHRAPDTLDSSPSSSSTPVSGCSSPNDSLPCENGLLPSAGGLSHEAHKILLRDGSLSSFTIQSPSTLPTITLGLPANSRAEGEVSPLKVSRVPMVTAGVSPVFLPISREDQGGQMGPHLPVIILEPSGLVHPPLLTVPSLDSVPIQFAHQLEHLSPGGVQPHKPLSRTRSEPLPQTLHTHLLQQQHNTQLLERLKQQTHLGKLMSKSSEKPRLHQIPSEDMDSEDGGGTSPSEPAYHNRVRAGSLREAETASSKSHEEQLQHALILNQSLLWEQQKQLQQLHRQMKTLAVPVLQGGGGGGVHRPLSRTQSSPASTSLSLPEKPLSLAAPETSSKPRFTTGLVYDSQMLKHQCACGDNSSHPEHAGRIQSIWSRLQERGLRGQCESIRGRKATLEELQSVHTERHVLLYGTNPLNRLKLDNRKLAGIFSQRMFTMLPCGGVGVDNDTIWNESHTSTASRMAAGSVVELAFRVAKGELKNGFAVVRPPGHHADPSNPMGFCYFNSVAIAAKQLQHKLSVSKILIVDWDVHHGNGTQEVFYNDPSVLYISLHRYDDGNFFPGSGSPAEVGSGAGKGFNVNVAWTGGLDPPMGDAEYLAAFRSVVIPIAQEFSPDVVLVSAGFDAAEGNPAPLGGYKVSAKCFGFLTHQLMSLAGGRLILALEGGHDLTAICDASEACVGALLGMQDPMPEDVLLQKPNANAVRSLQTVIQIQSQFWQNVKAHSGAVGLSQLAAQSRDCEETDAVNALASLSVGVMSNKSLQDEPMEHDSDPL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias161-181Basic and acidic residues
Compositional bias235-251Polar residues
Compositional bias292-314Polar residues
Compositional bias491-507Basic and acidic residues
Compositional bias590-607Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CM012443
EMBL· GenBank· DDBJ
RVE70160.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help