A0A437D4S3 · A0A437D4S3_ORYJA
- ProteinHistone deacetylase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1055 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Catalytic activity
- N6-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 638 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 640 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 646 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 723 | Zn2+ (UniProtKB | ChEBI) | |||
Active site | 775 | ||||
Site | 948 | Contributes to catalysis | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | histone deacetylase complex | |
Molecular Function | histone deacetylase activity | |
Molecular Function | metal ion binding | |
Biological Process | negative regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHistone deacetylase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Atherinomorphae > Beloniformes > Adrianichthyidae > Oryziinae > Oryzias
Accessions
- Primary accessionA0A437D4S3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-19 | ||||
Chain | PRO_5018974136 | 20-1055 | Histone deacetylase | ||
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 161-181 | Basic and acidic residues | |||
Region | 161-191 | Disordered | |||
Region | 207-314 | Disordered | |||
Compositional bias | 235-251 | Polar residues | |||
Compositional bias | 292-314 | Polar residues | |||
Region | 488-523 | Disordered | |||
Compositional bias | 491-507 | Basic and acidic residues | |||
Region | 582-617 | Disordered | |||
Compositional bias | 590-607 | Polar residues | |||
Domain | 646-963 | Histone deacetylase | |||
Sequence similarities
Belongs to the histone deacetylase family. HD type 2 subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,055
- Mass (Da)114,416
- Last updated2019-05-08 v1
- Checksum658454F121E31FF8
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 161-181 | Basic and acidic residues | |||
Compositional bias | 235-251 | Polar residues | |||
Compositional bias | 292-314 | Polar residues | |||
Compositional bias | 491-507 | Basic and acidic residues | |||
Compositional bias | 590-607 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CM012443 EMBL· GenBank· DDBJ | RVE70160.1 EMBL· GenBank· DDBJ | Genomic DNA |