A0A433JIG0 · A0A433JIG0_9GAMM
- ProteinBranched-chain-amino-acid aminotransferase
- GeneilvE
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids682 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Acts on leucine, isoleucine and valine.
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Catalytic activity
- 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate
Cofactor
Pathway
Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.
Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.
Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.
Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 2-isopropylmalate synthase activity | |
Molecular Function | L-isoleucine transaminase activity | |
Molecular Function | L-leucine transaminase activity | |
Molecular Function | L-leucine:2-oxoglutarate aminotransferase activity | |
Molecular Function | L-valine transaminase activity | |
Biological Process | isoleucine biosynthetic process | |
Biological Process | L-leucine biosynthetic process | |
Biological Process | valine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBranched-chain-amino-acid aminotransferase
- EC number
- Short namesBCAT
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Legionellales > Legionellaceae > Legionella
Accessions
- Primary accessionA0A433JIG0
Proteomes
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 9-271 | Pyruvate carboxyltransferase | ||||
Sequence: IIIFDTTLRDGEQAPGATMTLNQKIEIASALDCMGVDVIEAGFAAASSGDFQCIEQISQVVKSASVCSLARAKIADITAAGAAIKLALKPRIHTFISTSDLHLKYQFKITPDEALAAIESSVRSARNLCDDVEWSAMDATRSNIDFLARAVEIAINTGARTINIPDTVGYTTPQEYSDLIKALKNKVPNIDKAILSVHCHNDLGLAVANSIAAISAGARQVECTINGIGERAGNAAMEEIIMAIKTRPDQFPVVMNVDPTHIA |
Sequence similarities
Belongs to the alpha-IPM synthase/homocitrate synthase family.
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length682
- Mass (Da)74,150
- Last updated2019-05-08 v1
- Checksum23702B8C3DF39E6D
Keywords
- Technical term