A0A433JIG0 · A0A433JIG0_9GAMM

  • Protein
    Branched-chain-amino-acid aminotransferase
  • Gene
    ilvE
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Acts on leucine, isoleucine and valine.
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.
Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.
Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.
Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.

GO annotations

AspectTerm
Molecular Function2-isopropylmalate synthase activity
Molecular FunctionL-isoleucine transaminase activity
Molecular FunctionL-leucine transaminase activity
Molecular FunctionL-leucine:2-oxoglutarate aminotransferase activity
Molecular FunctionL-valine transaminase activity
Biological Processisoleucine biosynthetic process
Biological ProcessL-leucine biosynthetic process
Biological Processvaline biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Branched-chain-amino-acid aminotransferase
  • EC number
  • Short names
    BCAT

Gene names

    • Name
      ilvE
    • ORF names
      EKM59_07845

Organism names

  • Taxonomic identifier
  • Strain
    • km714
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Legionellales > Legionellaceae > Legionella

Accessions

  • Primary accession
    A0A433JIG0

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-271Pyruvate carboxyltransferase

Sequence similarities

Belongs to the alpha-IPM synthase/homocitrate synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    682
  • Mass (Da)
    74,150
  • Last updated
    2019-05-08 v1
  • Checksum
    23702B8C3DF39E6D
MTTATRDQIIIFDTTLRDGEQAPGATMTLNQKIEIASALDCMGVDVIEAGFAAASSGDFQCIEQISQVVKSASVCSLARAKIADITAAGAAIKLALKPRIHTFISTSDLHLKYQFKITPDEALAAIESSVRSARNLCDDVEWSAMDATRSNIDFLARAVEIAINTGARTINIPDTVGYTTPQEYSDLIKALKNKVPNIDKAILSVHCHNDLGLAVANSIAAISAGARQVECTINGIGERAGNAAMEEIIMAIKTRPDQFPVVMNVDPTHIAAVSELVSKASGFIVQKNKAIVGENAFAHESGIHQDGMLKCRETYEIMTPESVGFSGSKLSMGKHSGRAAFRNKLAALNIHVKEDVFAELFKQFKQIGDIQKEISDEDIIALVEGKTSIMQDTICPEKGVIWMDGQFIPWNDAQVPILTHGLHYASAVFEGERAYNGKVFKLHEHNERLHASASILGFTIPYSVAELNSITEELIRRNNLQDAYVRPIAWCGNETMSVASHSCTVHIAIVAWPWKSYFSDENSKTSGLKLMWADWIRPSPSTAPVTAKAAGLYMIGSLSKNKAEQAGFHDALMLDYRGFVAECTGANFFMVKNGVIHTPIADCFLNGITRQTVIAIAKNHHIPVIERHIHPHEVADADEIFITGSAVEVAAVSQIGNHFFEVGAITQAITSAYNKLVRGDDE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
RZGR01000022
EMBL· GenBank· DDBJ
RUQ85040.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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