A0A432U8N1 · A0A432U8N1_9GAMM

  • Protein
    ATP-dependent zinc metalloprotease FtsH
  • Gene
    hflB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

163750100150200250300350400450500550600
Type
IDPosition(s)Description
Binding site191-198ATP (UniProtKB | ChEBI)
Binding site413Zn2+ (UniProtKB | ChEBI); catalytic
Active site414
Binding site417Zn2+ (UniProtKB | ChEBI); catalytic
Binding site491Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processprotein catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent zinc metalloprotease FtsH
  • EC number

Gene names

    • Name
      hflB
    • Synonyms
      ftsH
    • ORF names
      DSZ20_03815

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • MAG 68
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Candidatus Thioglobus

Accessions

  • Primary accession
    A0A432U8N1

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-24
ChainPRO_501955305225-637ATP-dependent zinc metalloprotease FtsH

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain183-322AAA+ ATPase
Region614-637Disordered

Sequence similarities

Belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.
In the central section; belongs to the AAA ATPase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    637
  • Mass (Da)
    68,878
  • Last updated
    2019-05-08 v1
  • Checksum
    EB40DE8AAEB7C5C5
MFKNLLLWLVLGSVLTSIFSQFQGAEQTNEITYSQFIQSVKQGDVSGVTISGSNIKGVGAGGEQFSTYSPGDLGLMGDLLDNGVSVEAKPPEKDGFLKQLIISLAPILLLIGVILYTMKGAGGAMGGKNPMSFGKSKARLIPKDETNTSFDDVAGVDEAKEDVAELVDFLSNPGKFTKVGGKIPKGVLLIGPPGTGKTLLAKAIAGEADVPFFFISGSDFVEMFVGVGASRVRDMFEQAKKNAPCIIFIDEIDAVGRQRGAGMGGGHDEREQTLNQMLVEMDGFEGNEGIIVIAATNRPDVLDPALLRPGRFDRQVMVGLPDINGRDAILKIHMRKLPIAKNVQSISIAKGTPGFSGADLANLCNEAALLAAGKDIELVGMQEFEKAKDKIMMGAERKSMAMDEAEKEMTAYHEAGHAIVGRLVPEHDPVYKVSIIPRGRALGVTMFLPEKDSYSISRRKLNSQISSLFGGRIAEELIYGVDAVTTGASNDIERATEIAHKMVKHWGMSDLLGPLAYGEDEGEVFLGRQVTKHKHISEDTFKVIDSEIRKIIDVNYKVARKILEENKDILIEMTKALMEFETIDKDQIDDLMDRKPIREAAVIIDSDVVSTELGSGIEADENNDSDDKPVDGNPQVA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QOAI01000098
EMBL· GenBank· DDBJ
RUM86131.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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