A0A432FNS6 · A0A432FNS6_9GAMM

Function

function

Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N2-acetylornithine and glutamate.

Miscellaneous

Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N2-acetyl-L-ornithine (cyclic): step 1/1.
Amino-acid biosynthesis; L-arginine biosynthesis; N2-acetyl-L-ornithine from L-glutamate: step 1/4.

Features

Showing features for site, binding site, active site.

Type
IDPosition(s)Description
Site111Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Site112Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Binding site148substrate
Binding site174substrate
Site184-185Cleavage; by autolysis
Active site185Nucleophile
Binding site185substrate
Binding site271substrate
Binding site395substrate
Binding site400substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionglutamate N-acetyltransferase activity
Molecular FunctionL-glutamate N-acetyltransferase activity
Biological Processarginine biosynthetic process
Biological Processornithine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Including 2 domains:

  • Recommended name
    Glutamate N-acetyltransferase
  • EC number
  • Alternative names
    • Ornithine acetyltransferase
      (OATase
      )
    • Ornithine transacetylase
  • Recommended name
    Amino-acid acetyltransferase
  • EC number
  • Alternative names
    • N-acetylglutamate synthase
      (AGSase
      )

Gene names

    • Name
      argJ
    • ORF names
      DSZ00_06900
      , DSZ01_02105
      , DSZ02_03010

Organism names

Accessions

  • Primary accession
    A0A432FNS6

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_50349674941-184Arginine biosynthesis bifunctional protein ArgJ alpha chain
ChainPRO_5034967493185-400Arginine biosynthesis bifunctional protein ArgJ beta chain

Keywords

Interaction

Subunit

Heterotetramer of two alpha and two beta chains.

Family & Domains

Sequence similarities

Belongs to the ArgJ family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    400
  • Mass (Da)
    42,322
  • Last updated
    2019-05-08 v1
  • Checksum
    9EA8F6EFA0EFC03C
MNDPDIFPVPGIRLAATAAGIRYRDRDDLVLMELAEGSTTAAVFTRNAFCAAPVVVAREHLQKAAPRYLLINSGNANAGTGINGLTTCRETCRLLAAATGVPMDQVLPFSTGVIGEDLPTDPFAQAIPGLLRKLDEAGWPAAAEAIMTTDTVPKLSSRRIQVGGREVTVTGMAKGSGMIRPDMATMLAYVATDAQVPQPLLQSMLEAAVAPSFNAITVDGDTSTNDACVLVATGASGVTVERSDSPEGELLGEAVKAVCMELARAIVLDGEGATKLVEIRVEEAASEEEARQVAYTVAHSPLVKTALFASDPNWGRILAAVGRAGVEGLAIGSVRIWLDDVCIVRDGGRDPAYTEEAGQRVMAQREFGIRIALGRGEFATRILTCDLSFDYVRINAEYRT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QNZO01000135
EMBL· GenBank· DDBJ
RTZ73186.1
EMBL· GenBank· DDBJ
Genomic DNA
QNZQ01000061
EMBL· GenBank· DDBJ
RTZ75619.1
EMBL· GenBank· DDBJ
Genomic DNA
QNZP01000089
EMBL· GenBank· DDBJ
RTZ80513.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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