A0A432F810 · A0A432F810_UNCVE

Function

function

Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.
One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for active site, binding site, site.

Type
IDPosition(s)Description
Active site9Nucleophile
Active site15
Active site124Proton donor
Binding site430(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Binding site434-436(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Site538Plays an important role in substrate specificity
Binding site662-664(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncobalt ion binding
Molecular Functionglycine hydroxymethyltransferase activity
Molecular Functionintramolecular oxidoreductase activity, interconverting aldoses and ketoses
Molecular Functionprotein tyrosine phosphatase activity
Molecular Functionpyridoxal phosphate binding
Molecular Functionserine binding
Molecular Functionzinc ion binding
Biological Processcarbohydrate metabolic process
Biological Processfolic acid metabolic process
Biological Processglycine biosynthetic process from serine
Biological ProcessL-serine catabolic process
Biological Processprotein dephosphorylation
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine hydroxymethyltransferase
  • EC number
  • Short names
    SHMT
    ; Serine methylase

Gene names

    • Name
      rpiB
    • Synonyms
      glyA
    • ORF names
      DSZ35_06140

Organism names

Accessions

  • Primary accession
    A0A432F810

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue539N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-150Phosphotyrosine protein phosphatase I

Sequence similarities

Belongs to the LacAB/RpiB family.
Belongs to the SHMT family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    724
  • Mass (Da)
    77,757
  • Last updated
    2019-05-08 v1
  • Checksum
    8949679EB04198A7
MAHTILFICTGNVCRSPMAEGLFKNLVDQNKADLIVKSAGVGAQNGQPPSENAIRAMQDLEIDISPQRSLMMTAELASEADMIIGMTHGHIEMVNLMFPHATEKTFLLREFDDSLPLHEREIPDPLGGSYETYCQCRDQIREGIDSLLESIQKNNGLIPGSTQPVVEMALGADHAGYGLKKILGHYLGEKGIPYADFGCDSEDKADYPDFAREVAQTVAGGQSRLGLLICNTGVGMSMSANKVPGVRAALAHDEETARLTRQHNNANVLCLGAAATDEALAKRILDAFIETRFEDGGRHERRVNKMEPDVAPGSRRLDTVDPEIAQAIRAETSRQQENIELIASENFTSPAVMQAQGSVLTNKYAEGYPARRWYGGCEHVDVAEQLAIERAKQIFGAEHANVQPHSGSGANMAVYFSALQPGDKILTMDLSHGGHLTHGHKANFSGRFYAVTHYGVSKETERIDYDALAKVAAREKPAMITVGASAYPRVIDFERVGQIARGVGALLLADIAHIAGLVAAGLHPSPVGHADFVTTTTHKTLRGPRGGLILCGAEQAKAIDSQTFPGIQGGPLMHVIAAKAVCLKEALQPAFAEYQAQVVANAAALAKGLAKNGFRLVSGGTDNHLMLVDVGSRDMTGKECQAALDEAGITVNKNTIPFETRSPFQASGIRIGSPAVTTRGMGEAEMADIADMISEVLLDINNVDKQAAVRQRVRQLTVGFPLPY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QOAX01000174
EMBL· GenBank· DDBJ
RTZ67544.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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