A0A432ETX0 · A0A432ETX0_9GAMM

Function

function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

164650100150200250300350400450500550600
Type
IDPosition(s)Description
Binding site196-203ATP (UniProtKB | ChEBI)
Binding site418Zn2+ (UniProtKB | ChEBI); catalytic
Active site419
Binding site422Zn2+ (UniProtKB | ChEBI); catalytic
Binding site495Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processcell division
Biological Processprotein catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent zinc metalloprotease FtsH
  • EC number

Gene names

    • Name
      ftsH
    • ORF names
      DSZ32_00760
      , DSZ33_05480

Organism names

Accessions

  • Primary accession
    A0A432ETX0

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane7-25Helical
Transmembrane102-123Helical

Keywords

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain188-327AAA+ ATPase
Region595-646Disordered
Compositional bias603-620Polar residues
Compositional bias621-646Basic and acidic residues

Sequence similarities

Belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.
In the central section; belongs to the AAA ATPase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    646
  • Mass (Da)
    71,120
  • Last updated
    2019-05-08 v1
  • Checksum
    E1376D8546A088DE
MNNLTKNLALWLVIAMVLMAVFNNFEPHSDLTASGRMDYSAFISEVKQGRIARATIDGHNITGVTQDGKVFETYAPDDPGLMGDLLANGVTVNAKPEEQPSLLAQIFISWFPLLLLIGVWIFFMRQMQGGGGRGAMSFGKSRAKMLTEDKNKITFDDVAGIEEAKDEVSELVEFLKDPSRFQKLGGRIPRGVLMTGSPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGVGASRVRDMFEQAKKNAPCIIFIDEIDAVGRQRGAGLGGGNDEREQTLNQLLVEMDGFEANDGVIVIAATNRPDVLDPALLRPGRFDRQVNVPLPDILGREKILLVHMKKIPVADDVQAKVIARGTPGFSGADLANLVNEAALFAARAGVKEVSMSHFELAKDKILMGAERRSMVMPEDERKNTAYHESGHTVVAKVLAPLTDPVHKVTIIPRGRALGVTMQLPEEDRYSHNRKYLLATIAVLMGGRIAEEVFMDQMTTGASNDFERATDIARKMVTRWGMSDKLGPRVYGDNESEVFLGRDVTTHKNLSDSTAQMVDEEIQRIIDEQYHRARKIIEDNREKIELMAQTLLEWETLQADQIEDIMSGKPPRSPEESTGSFDNKSGNDNKSGKPAVKDDKKGTKPKPHMDKPASEH

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias603-620Polar residues
Compositional bias621-646Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QOAV01000184
EMBL· GenBank· DDBJ
RTZ58739.1
EMBL· GenBank· DDBJ
Genomic DNA
QOAU01000020
EMBL· GenBank· DDBJ
RTZ62286.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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