A0A432EH73 · A0A432EH73_9GAMM

Function

function

Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

FMNH2 (UniProtKB | Rhea| CHEBI:57618 )

Note: Reduced FMN (FMNH2).

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site44NADP+ (UniProtKB | ChEBI)
Binding site50NADP+ (UniProtKB | ChEBI)
Binding site133-135FMN (UniProtKB | ChEBI)
Binding site253-254FMN (UniProtKB | ChEBI)
Binding site298FMN (UniProtKB | ChEBI)
Binding site313-317FMN (UniProtKB | ChEBI)
Binding site339FMN (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionchorismate synthase activity
Molecular FunctionFMN binding
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Chorismate synthase
  • EC number
  • Short names
    CS
  • Alternative names
    • 5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

    • Name
      aroC
    • ORF names
      DSZ31_05730

Organism names

Accessions

  • Primary accession
    A0A432EH73

Proteomes

Subcellular Location

Interaction

Subunit

Homotetramer.

Family & Domains

Sequence similarities

Belongs to the chorismate synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    390
  • Mass (Da)
    43,264
  • Last updated
    2019-05-08 v1
  • Checksum
    F7E8E2A8EB963142
MSLRVLRFLTAGESHGKGLVAILEGIPANLEICAEDINRELARRQRGYGRGGRMKIEKDRVEFISGVRFGKTIGSPIAMAIWNRDYENWKEKMATEGQPPQGYTPFTRPRPGHADLAGGIKYNQRDLRNILERSSARETAARVAVGAVCKKFLSEFGIKIGSYVRVLGGYKVKEMPIDLWSRHLKAEQSEVRIPNPLEDNFVKTLIDKAKEKGETLGGIIEVFALNVPPGLGSHIQWDRRLDGRIAQAMMSIQAIKGVEIGSGFETGFLPGSKVMDEIGWREDKGFFRYTNHLGGTEGGITNGQPIVVRIAMKPIPTLMSPLRSVDINTKEEVKASRERSDVTAVPAASVVAEAMLAIVLADALLEKLGGDFMEEVKERFELYLKHIKSF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QOAS01000154
EMBL· GenBank· DDBJ
RTZ58526.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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