A0A432EGB0 · A0A432EGB0_9GAMM

Function

function

Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.
    EC:3.4.16.4 (UniProtKB | ENZYME | Rhea)

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Features

Showing features for active site.

158350100150200250300350400450500550
TypeIDPosition(s)Description
Active site300Acyl-ester intermediate

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionpenicillin binding
Molecular Functionpeptidoglycan glycosyltransferase activity
Molecular Functionserine-type D-Ala-D-Ala carboxypeptidase activity
Biological Processcell wall organization
Biological Processdivision septum assembly
Biological ProcessFtsZ-dependent cytokinesis
Biological Processpeptidoglycan biosynthetic process
Biological Processproteolysis
Biological Processregulation of cell shape

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Peptidoglycan D,D-transpeptidase FtsI
  • EC number
  • Alternative names
    • Penicillin-binding protein 3
      (PBP-3
      )

Gene names

    • Name
      ftsI
    • ORF names
      DSZ32_07500
      , DSZ33_01275

Organism names

Accessions

  • Primary accession
    A0A432EGB0

Proteomes

Subcellular Location

Cell inner membrane
; Single-pass membrane protein
Membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane21-40Helical

Keywords

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain64-213Penicillin-binding protein dimerisation
Domain253-549Penicillin-binding protein transpeptidase
Region560-583Disordered

Sequence similarities

Belongs to the transpeptidase family. FtsI subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    583
  • Mass (Da)
    63,813
  • Last updated
    2019-05-08 v1
  • Checksum
    C9C23DD9FE13F732
MARRKNHQKFTSSRRPGGARRFFALTLVLGIMGLLGLRAFQLQVADHNFLQGQADARSLRTITVQPMRGMITDRNGRPLAVSAPVDSVAADPVKLAASPTRFRELEKALGMGRGEIQKKLKRYKGKRFMWLKRQLVPEQAEKVDALNIAGVWLKRDFKRYYPFSYMASHVVGFTGTDNVGLEGLERAYDEALRGVPGKQRVLKDMTGRIIERVENLQSGVPGENVVSSIDSRLQYIASRELYTAVKKHKARGGSVVVLDVNTGEILAMANEPGYNPNNRKGVSARAFQNRAVNYTYEPGSTMKTFTILSALSDNLVNAESRIDTSPGYLQIGRFTVHDHTNMGMLTVSLVLKKSSNVGAAKIADRLSNERMWKTLDLAGFGHAPGSGLPGESKGRLPNYSGWKRSEKITMAYGYHIAVTPLQLARAYGVIARGGRQFPVTILKHEEPVDGEQVFDPKKVAQLTRMLEGVVEKGGTAPLAAVDHYQVAGKTGTAHKIKHGAYSKKDYVGSFAGFAPSSHPRLVVAVMIDEPSNGKHFGGDVAGPVFRNVMAESLRLLNVEPEIGPDSPSIRRADVRSGGVQHAG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QOAU01000228
EMBL· GenBank· DDBJ
RTZ58176.1
EMBL· GenBank· DDBJ
Genomic DNA
QOAV01000048
EMBL· GenBank· DDBJ
RTZ61319.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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