A0A431UP10 · A0A431UP10_STEMA
- ProteinDNA topoisomerase 4 subunit B
- GeneparE
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids629 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Catalytic activity
Cofactor
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 5 | ATP (UniProtKB | ChEBI) | |||
Binding site | 42 | ATP (UniProtKB | ChEBI) | |||
Binding site | 69 | ATP (UniProtKB | ChEBI) | |||
Binding site | 110-116 | ATP (UniProtKB | ChEBI) | |||
Binding site | 333 | ATP (UniProtKB | ChEBI) | |||
Site | 445 | Interaction with DNA | |||
Site | 496 | Interaction with DNA | |||
Site | 614 | Interaction with DNA | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromosome | |
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity | |
Biological Process | chromosome segregation | |
Biological Process | DNA topological change |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA topoisomerase 4 subunit B
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Lysobacterales > Lysobacteraceae > Stenotrophomonas > Stenotrophomonas maltophilia group
Accessions
- Primary accessionA0A431UP10
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Heterotetramer composed of ParC and ParE.
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 411-524 | Toprim | |||
Region | 610-629 | Disordered | |||
Sequence similarities
Belongs to the type II topoisomerase GyrB family.
Belongs to the type II topoisomerase family. ParE type 1 subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length629
- Mass (Da)69,357
- Last updated2019-05-08 v1
- ChecksumDD668008689856DF
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
RXLZ01000004 EMBL· GenBank· DDBJ | RTQ91765.1 EMBL· GenBank· DDBJ | Genomic DNA |