A0A431UD79 · A0A431UD79_STEMA

Function

function

Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 2/2.
Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular Functiondihydrofolate synthase activity
Molecular Functionmetal ion binding
Molecular Functiontetrahydrofolylpolyglutamate synthase activity
Biological Processtetrahydrofolate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydrofolate synthase/folylpolyglutamate synthase
  • EC number
  • Alternative names
    • Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase
    • Folylpolyglutamate synthetase
    • Tetrahydrofolylpolyglutamate synthase

Gene names

    • ORF names
      EKL94_16270

Organism names

Accessions

  • Primary accession
    A0A431UD79

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain49-200Mur ligase central
Domain287-409Mur ligase C-terminal

Sequence similarities

Belongs to the folylpolyglutamate synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    423
  • Mass (Da)
    44,375
  • Last updated
    2019-05-08 v1
  • Checksum
    8DB4C1BA908AB792
MTNTPTTLADWLDYIERQHPATIDMGLERVHAVATAMGLGAPAGRTIVVGGTNGKGSTVAFIEAIGRAAGWKVGAYTSPHLLRYNERVRIDGQDVDDAALVAAFNAIEAARGEITLTYFEYGTLAALQLFADAGLDLAVLEVGLGGRLDAVNIVDADVAVITTVDIDHAEWLGEDREAIGTEKAGIIRGWKPVILGETDPPSSVLARAYLVGANAIRGGSDYFYEPIDAQRWRWRDVGLRMELPTPALAGPIQLANAGAAIAALRALDKPVPRAAWAAGIAAARISGRMQAFEREGVQIRVDVGHNPQAAGQLARTLKAEVSAGRTLAVYAALQDKDAVGVVQALQDVVGEWTLAGLDGPRGQSAAQLQARLAGTAAAKAQLADSVEQALAQVLAQAERGDRVLVFGSFHTAAAALQMLQGDA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
RXLZ01000052
EMBL· GenBank· DDBJ
RTQ87084.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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