A0A426UKU5 · A0A426UKU5_9ACTN

  • Protein
    Serine hydroxymethyltransferase
  • Gene
    glyA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.
One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site135(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Binding site139-141(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Site243Plays an important role in substrate specificity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionglycine hydroxymethyltransferase activity
Molecular Functionmethyltransferase activity
Molecular Functionpyridoxal phosphate binding
Biological Processglycine biosynthetic process from serine
Biological Processmethylation
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine hydroxymethyltransferase
  • EC number
  • Short names
    SHMT
    ; Serine methylase

Gene names

    • Name
      glyA
    • ORF names
      EHS43_10590

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • RP5T
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces

Accessions

  • Primary accession
    A0A426UKU5

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue244N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-16Polar residues
Region1-22Disordered
Domain24-403Serine hydroxymethyltransferase-like

Sequence similarities

Belongs to the SHMT family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    438
  • Mass (Da)
    46,598
  • Last updated
    2019-05-08 v1
  • Checksum
    43DBB836AE69B87F
MATSTSSTSPLTTPASPLSLPLGELDPEVAGAVAAELRRQQATLEMIASENFAPAAVMEAQGSVLTNKYAEGYPGRRYYGGCEHVDVVERLAIARVKELFGAEAANVQPHSGAQANAAAMFALLKPGDTILGLDLAHGGHLTHGMRLNYSGKLYDVVPYHVRESDLRIDMDEVEQLALAHRPKMIVAGWSAYPRQLDFAGFRRIADAVGAYLLVDMAHFAGLVAAGLHPSPVPYADVVTTTTHKTLGGPRGGVILSRADLAKKINSAVFPGQQGGPLEHVIAAKAVAFKVAAGEEFKERQRRTLRGAKILAGRLLADDVAEAGITVLTGGTEVHLILVDLRKSELDGKQAEDRLHRIGITVNRNAVPFDPRPPMVSSGLRIGTPALATRGFGDTEFREVADIIAGTLKGDRPDDELRARVEKLAAAFPLYPHLDGGAA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-16Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
RSAJ01000069
EMBL· GenBank· DDBJ
RRR84752.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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