A0A424Z2V5 · A0A424Z2V5_9BACT
- Protein6,7-dimethyl-8-ribityllumazine synthase
- GeneribH
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids154 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
Catalytic activity
- (2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H+ + 2 H2O + phosphate
Pathway
Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 23 | 5-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI) | ||||
Sequence: F | ||||||
Binding site | 57-59 | 5-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI) | ||||
Sequence: VFE | ||||||
Binding site | 81-83 | 5-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI) | ||||
Sequence: AVI | ||||||
Binding site | 86-87 | (2S)-2-hydroxy-3-oxobutyl phosphate (UniProtKB | ChEBI) | ||||
Sequence: ST | ||||||
Active site | 89 | Proton donor | ||||
Sequence: H | ||||||
Binding site | 114 | 5-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI) | ||||
Sequence: F | ||||||
Binding site | 128 | (2S)-2-hydroxy-3-oxobutyl phosphate (UniProtKB | ChEBI) | ||||
Sequence: R |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | riboflavin synthase complex | |
Molecular Function | 6,7-dimethyl-8-ribityllumazine synthase activity | |
Biological Process | riboflavin biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name6,7-dimethyl-8-ribityllumazine synthase
- EC number
- Short namesDMRL synthase ; LS ; Lumazine synthase
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Campylobacterota > Epsilonproteobacteria > Campylobacterales > Campylobacteraceae > Campylobacter
Accessions
- Primary accessionA0A424Z2V5
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length154
- Mass (Da)16,789
- Last updated2019-05-08 v1
- ChecksumEA6A8EF45AAB3DE2
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP031611 EMBL· GenBank· DDBJ | AXP09475.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WHMG01000002 EMBL· GenBank· DDBJ | MPV95055.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WHMF01000003 EMBL· GenBank· DDBJ | MPV98007.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QURW01000001 EMBL· GenBank· DDBJ | RQD88655.1 EMBL· GenBank· DDBJ | Genomic DNA |