A0A422PBE5 · A0A422PBE5_9TRYP

  • Protein
    Lysosomal dipeptide transporter MFSD1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentlysosomal membrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      Tco025E_05618

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 025E
  • Taxonomic lineage
    Eukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Trypanosoma

Accessions

  • Primary accession
    A0A422PBE5

Proteomes

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane79-99Helical
Transmembrane111-130Helical
Transmembrane168-188Helical
Transmembrane200-224Helical
Transmembrane254-276Helical
Transmembrane296-314Helical
Transmembrane321-339Helical
Transmembrane345-364Helical
Transmembrane376-402Helical
Transmembrane442-460Helical

Keywords

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain29-466Major facilitator superfamily (MFS) profile

Sequence similarities

Belongs to the major facilitator superfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    505
  • Mass (Da)
    54,979
  • Last updated
    2019-05-08 v1
  • Checksum
    427EDA027337C169
MDASATLCGAAEAEKRWYEVLKEEVLELRWRVLVVACFLTFGSYYIFDFPGSIGTGEGATIEQRFKTHGKEYTQKMNQLLYSVYSWPNTVLAVFGGVLIDKFLGIRKAMLLFTFCILLGASFFWLGVYYVVYPLMLIARVVFGLGGESLSVAQSAYVARWFKHSRGMALAFGITISFSRVGSSFNFLFSPMIAEARGVEVAALFGILSCVVSFCACIILVFADVHAVRTGYIRQEPREAGSGVMKLTDAVRLPFAFWALTIICVFCYSAIFPFIGLGVNFFEVKYEYTTRTASNYISAYQFASAAGSPLVGLVVDNVGRNTLWLIAASASFLLIHLLLLTTMIPGIVMMIIMGVSYSVLVSGLWPSVPWAVGENVLGLSYGVIMAVQNVGLALFPIIVGSILDRYVPDTTGKGAAADSSSSQASADDVRPLPTLKGYQMAEMVFIAAATVSLLASVVLLVSDVRHGGALTASNTRRKEMAAEKRAALLESLPDEERALMFAQHDS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MKKU01000341
EMBL· GenBank· DDBJ
RNF15034.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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