A0A421DB11 · A0A421DB11_9EURO

  • Protein
    GTP cyclohydrolase 1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site1717ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcyclin/CDK positive transcription elongation factor complex
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functioncyclin binding
Molecular FunctionGTP cyclohydrolase I activity
Molecular FunctionRNA binding
Molecular FunctionRNA polymerase II CTD heptapeptide repeat kinase activity
Molecular Functiontranslation initiation factor activity
Biological Processfolic acid biosynthetic process
Biological Processpositive regulation of transcription elongation by RNA polymerase II
Biological Processprotein phosphorylation
Biological Processtetrahydrofolate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GTP cyclohydrolase 1
  • EC number
  • Alternative names
    • GTP cyclohydrolase I

Gene names

    • ORF names
      CFD26_107496

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • HMR AF 1038
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Fumigati

Accessions

  • Primary accession
    A0A421DB11

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region1-147Disordered
Compositional bias18-32Polar residues
Compositional bias109-123Polar residues
Compositional bias300-316Polar residues
Region300-329Disordered
Compositional bias617-646Polar residues
Region617-655Disordered
Region683-731Disordered
Compositional bias697-724Polar residues
Region1039-1084Disordered
Region1289-1361Disordered
Compositional bias1328-1359Polar residues
Region1471-1677Disordered
Compositional bias1491-1523Polar residues
Compositional bias1555-1574Pro residues
Compositional bias1575-1656Basic and acidic residues
Domain1688-1973Protein kinase
Compositional bias2000-2042Basic and acidic residues
Region2000-2115Disordered
Compositional bias2043-2062Polar residues
Compositional bias2071-2087Basic and acidic residues
Compositional bias2088-2115Polar residues
Compositional bias2130-2145Polar residues
Region2130-2175Disordered
Compositional bias2146-2160Basic and acidic residues
Compositional bias2161-2175Polar residues
Region2348-2389Disordered

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,389
  • Mass (Da)
    266,607
  • Last updated
    2019-05-08 v1
  • Checksum
    9F734B88F828C28B
MGSGSPPLGPKPKSAIPSHLLNGSSPLHPSNTTGVRDARERESLNSSIRSSFAPRIPAEFDLPETETRRVSDAADTYNGAVRDSGIVRPTLSDPPRDPRDKGGALTPPASASRPSSPYTSNPPIDFDGLSWPCPGTRERLESTPEQTEERIQKLAGAVRTIFECIGEDPEREGLRGTPERYAKAMLYFTKGYEENVRDLVNGAVFHEDHDELVIVKDIEVFSLCEHHMVPFTGKMHIGYIPDRRVLGLSKLARLAEMFSRRLQVQERLTKQVALAISEVLKPRGVGVVMESSHLCMVMRGVQKTSSTTTTSSDRKQSKAPTRPERTADELEAGEALILLSRGYGERTAGPRQPSNTNMQTQNDQRNFQTQNNRGVPANTIARPHQNMTLAQEGGRMQMPQNVPQQPANAAVPAMQAAPYWNANPAAAQRVALTGQEALQAYLIRQQILAGVAPQDLIMMRGPPQHGRQAVPPLVQITNQGVYAPVIPPATFNGVFHPFPMLPVQQNIPNVPAPTAAPGVPYPAVAPGIPPQASQAARAPQCHCPPNGHIMPQEAGQFQVQRPLNRNHPNAAAMAGLNASMPAQNRAVLPAARQLNGQQPQDPYLPPARTIVERNVNTPANNMPVRDNGTLDKTAGFQRQSGKAPQIKTESPAPEEVLANQVDHTGIRRTVLEANGHRRLLPQPHIALQPPNDGHRPASNGPDTTQASAPPTTAAQSSKNAAQHTRNRSKSSRRHMYNMLKCLICHPSMAFLVFDHLEIEDVINLLLTCKRVHEFVKSVLAIIVMRKAAQKAPKSLWTFPFLCYNRLCDRSSVPPGVKLNDVTYLIPSVRWLKMLLYREAVVKDIIDRMAEMGWKLPNRCATVVKKLWFLMDIRDNSRRTWTIRKKTLWTDNDLFLAAYFIVQLDMLFTDSRARKKQGSMRRLLMAQPSLTLLWDVLRDRTLTTHYETLKAYVRWQYIPPAHEAGLFVFGVPPNEVGSLQWEGYGRMARNVKFQRPDELVLKEIKDRNLDMRRMYVDIILSDEPEPKEDASPYRWHEEIMKDGAPPSTPEIRGTEEGRGLEGRTVTEGETDSATESVVAGPKRTHLSPRYGRRHLRVVIPNQSLEDLVHIVNSLLITHLLVAHPVCRTLSPDNGRIKIVTNLASLSLRKPRERPEEIIEGTILHLHLLHSSEREHRVRPQGVPIHLNKTRSITVHLLSGLTNSIGATLIKNVDDFRGVVGRVEGHLEEEETGAGRNRIASRVPSPLHVVPGHRGTTESDLAARSLQATLTESIAIGRLLAIPFAQLSAMDSSFRSPSPPRPIPSFDAESTGVPPDGDPNGRETLPFHGQRALNANNNQRSHPSRPHVDTSQYSTSPKYGPSSRKGLHIPLHIVKTIILHRAARKSSTIKVKHRRLVQRTIINRIRVLPTVVGIQVIVETSKITAATGDFLALVTHPTILGRPHEAVLTVSNGALAAAAALTALIRLMRNPHKVRRPCQGQKSRACRDLQGVDQGSKPSSENGDFQKMSRPTQPSDTNSTPNKGGKFSFAFKAKTTPAPAPKPVPDLAQRMQAREPPPRVAEPPRSRVPLGPPPRFKPEPRFDRRDRDRDRDRHRNRDRDRGRRDRRDLRRDPRDFREPRDIRDNRKEDRRFDQRHEGRKDDRRQDPRPPRGPRERSPGVKQPRILTRPKPRPTLPEEYAKSDSVYYRKPGNESVIGAGTYGKVFKAIHVYTQRKVALKKIRMEGEKDGFPVTAVREIKLLQHLRNHNVVSLLEVMVERNECFMVFEYLSHDLTGLINHPTFSLTAAHKKDLAKQMFEGLNYLHHRSVLHRDIKAANILISNRGLLKFADFGLARFFSKSRQLDYTNRVITIWYRPPELLLGETRYGPAVDVWSAGCVFVELFTKKAVFPGEGGEISQLEKLYNSLGTPTRAEWPDLVEMPWFELMRPTERKKRVFEDVYGEILSPAALDLVSQIFRYDPAKRPSAEEVLTHSYFVSEEPAPQQAIELENIEGDWHEFESKALRKEKDKEARRAEYQKDKEKRKVASSAPQSDRETKRVRQDVEENPQPSAQPTEHSAKLSLSMTGTDGKDGGARVDLPRSHTSKRFGPDSSHGGRSNPFNALSPLSGGVSSPSTNASSAFGLGSGAFASFGTPKTPGTSTSDLNSSKALGEKRETASEQDSAAEVKSKASASSLTGQREHALKSTWVIWYRPPTPKYSDYEKSTVPLASISSVESFWSIYTHLKRPSLLPTVSDYHIFKKGIRPVWEDDANKKGGKWIVRLKKGVADRYWEDLLLAMIGDQFAEASDEVCGAVLSVRSGEDVLSVWTRIDGGRNIKIRETIKRLLAFPADTNIVWKSHDDSIAQRSAIDQARQEKAAGNAGHHHHHLAGDRRRPTANDESLGDKGKAAAS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias18-32Polar residues
Compositional bias109-123Polar residues
Compositional bias300-316Polar residues
Compositional bias617-646Polar residues
Compositional bias697-724Polar residues
Compositional bias1328-1359Polar residues
Compositional bias1491-1523Polar residues
Compositional bias1555-1574Pro residues
Compositional bias1575-1656Basic and acidic residues
Compositional bias2000-2042Basic and acidic residues
Compositional bias2043-2062Polar residues
Compositional bias2071-2087Basic and acidic residues
Compositional bias2088-2115Polar residues
Compositional bias2130-2145Polar residues
Compositional bias2146-2160Basic and acidic residues
Compositional bias2161-2175Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NIDN02000034
EMBL· GenBank· DDBJ
RLL99324.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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