A0A421DB11 · A0A421DB11_9EURO
- ProteinGTP cyclohydrolase 1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids2389 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
Pathway
Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 1717 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cyclin/CDK positive transcription elongation factor complex | |
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | cyclin binding | |
Molecular Function | GTP cyclohydrolase I activity | |
Molecular Function | RNA binding | |
Molecular Function | RNA polymerase II CTD heptapeptide repeat kinase activity | |
Molecular Function | translation initiation factor activity | |
Biological Process | folic acid biosynthetic process | |
Biological Process | positive regulation of transcription elongation by RNA polymerase II | |
Biological Process | protein phosphorylation | |
Biological Process | tetrahydrofolate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGTP cyclohydrolase 1
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Fumigati
Accessions
- Primary accessionA0A421DB11
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-147 | Disordered | |||
Compositional bias | 18-32 | Polar residues | |||
Compositional bias | 109-123 | Polar residues | |||
Compositional bias | 300-316 | Polar residues | |||
Region | 300-329 | Disordered | |||
Compositional bias | 617-646 | Polar residues | |||
Region | 617-655 | Disordered | |||
Region | 683-731 | Disordered | |||
Compositional bias | 697-724 | Polar residues | |||
Region | 1039-1084 | Disordered | |||
Region | 1289-1361 | Disordered | |||
Compositional bias | 1328-1359 | Polar residues | |||
Region | 1471-1677 | Disordered | |||
Compositional bias | 1491-1523 | Polar residues | |||
Compositional bias | 1555-1574 | Pro residues | |||
Compositional bias | 1575-1656 | Basic and acidic residues | |||
Domain | 1688-1973 | Protein kinase | |||
Compositional bias | 2000-2042 | Basic and acidic residues | |||
Region | 2000-2115 | Disordered | |||
Compositional bias | 2043-2062 | Polar residues | |||
Compositional bias | 2071-2087 | Basic and acidic residues | |||
Compositional bias | 2088-2115 | Polar residues | |||
Compositional bias | 2130-2145 | Polar residues | |||
Region | 2130-2175 | Disordered | |||
Compositional bias | 2146-2160 | Basic and acidic residues | |||
Compositional bias | 2161-2175 | Polar residues | |||
Region | 2348-2389 | Disordered | |||
Sequence similarities
Belongs to the GTP cyclohydrolase I family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,389
- Mass (Da)266,607
- Last updated2019-05-08 v1
- Checksum9F734B88F828C28B
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 18-32 | Polar residues | |||
Compositional bias | 109-123 | Polar residues | |||
Compositional bias | 300-316 | Polar residues | |||
Compositional bias | 617-646 | Polar residues | |||
Compositional bias | 697-724 | Polar residues | |||
Compositional bias | 1328-1359 | Polar residues | |||
Compositional bias | 1491-1523 | Polar residues | |||
Compositional bias | 1555-1574 | Pro residues | |||
Compositional bias | 1575-1656 | Basic and acidic residues | |||
Compositional bias | 2000-2042 | Basic and acidic residues | |||
Compositional bias | 2043-2062 | Polar residues | |||
Compositional bias | 2071-2087 | Basic and acidic residues | |||
Compositional bias | 2088-2115 | Polar residues | |||
Compositional bias | 2130-2145 | Polar residues | |||
Compositional bias | 2146-2160 | Basic and acidic residues | |||
Compositional bias | 2161-2175 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
NIDN02000034 EMBL· GenBank· DDBJ | RLL99324.1 EMBL· GenBank· DDBJ | Genomic DNA |