A0A420I6H1 · A0A420I6H1_9PEZI

  • Protein
    Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site37ATP (UniProtKB | ChEBI)
Binding site44-46ATP (UniProtKB | ChEBI)
Binding site105ATP (UniProtKB | ChEBI)
Binding site197Mg2+ (UniProtKB | ChEBI)
Binding site211Mg2+ (UniProtKB | ChEBI)
Binding site262substrate; ligand shared with subunit alpha
Binding site319-321substrate; ligand shared with subunit alpha

GO annotations

AspectTerm
Cellular Componentmitochondrion
Cellular Componentsuccinate-CoA ligase complex
Molecular FunctionATP binding
Molecular Functionmagnesium ion binding
Molecular Functionsuccinate-CoA ligase (ADP-forming) activity
Biological Processsuccinyl-CoA metabolic process
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
  • EC number
  • Alternative names
    • Succinyl-CoA synthetase beta chain
      (SCS-beta
      )

Gene names

    • ORF names
      OnM2_010017

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • UMSG2
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Leotiomycetes > Erysiphales > Erysiphaceae > Erysiphe

Accessions

  • Primary accession
    A0A420I6H1

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Heterodimer of an alpha and a beta subunit.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-200ATP-grasp fold succinyl-CoA synthetase-type
Domain260-380ATP-citrate synthase/succinyl-CoA ligase C-terminal

Sequence similarities

Belongs to the succinate/malate CoA ligase beta subunit family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    402
  • Mass (Da)
    43,233
  • Last updated
    2019-05-08 v1
  • Checksum
    9B1CDDBD06CB0E9B
MTFSQYGVGVPKGSVAKTGAQAEIAAKQIGGDDLVIKAQVLAGGRGKGIFDNGFKGGVRVLYSQSDAKPLAEKMIGHNLITKQTGAHGRPCNSVYICERKFARREFYLAILMDRASAAPVIVSSSQGGMDIETVAKENPEAIKTTRINIHEGVTDKIAREISKDLGFSERCIEDAMVVIKRLYQLFVEKDATQVEINPLSETIDHKVLAMDAKLGFDDNAEFRQKDIFALRDTTQEDPDEVLAAESGLNFIKLGGDIGCVVNGAGLAMATMDIIKLNGGDPANFLDVGGNATPKAIYNAFTLITSDPKVTAIFVNIFGGIVRCDAIAEGLISIVKQMNLRVPIIVRLKGTNMEVANQLIAESGLKIFSIDDLQTAAEKSVQFSKIVKMARNVDVGVEFSLGT

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MCFK01001096
EMBL· GenBank· DDBJ
RKF65265.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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