A0A420H7L1 · A0A420H7L1_9PEZI
- ProteinUbiquinone biosynthesis O-methyltransferase, mitochondrial
- GeneCOQ3
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids312 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
Catalytic activity
- 3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H+ + S-adenosyl-L-homocysteine
3,4-dihydroxy-5-all-trans-polyprenylbenzoate RHEA-COMP:10930 + CHEBI:59789 = 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate RHEA-COMP:10931 + CHEBI:15378 + CHEBI:57856
Pathway
Cofactor biosynthesis; ubiquinone biosynthesis.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 85 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 125 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 148 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 197 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: F |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extrinsic component of mitochondrial inner membrane | |
Molecular Function | 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity | |
Molecular Function | 3-demethylubiquinol-n 3-O-methyltransferase activity | |
Biological Process | methylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUbiquinone biosynthesis O-methyltransferase, mitochondrial
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Leotiomycetes > Erysiphales > Erysiphaceae > Erysiphe
Accessions
- Primary accessionA0A420H7L1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Peripheral membrane protein
Keywords
- Cellular component
Interaction
Subunit
Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 122-225 | Methyltransferase type 11 | ||||
Sequence: LDVGCGGGIFAESAARLSNVRSVTAIDPTPDVIAVAKAHARRDPLLQSKLTYRNISIENMKTPTLKDDQFDILTLFEVIEHITYPAEFLEQCTKFVRPGGWIVI |
Sequence similarities
Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length312
- Mass (Da)35,117
- Last updated2019-05-08 v1
- Checksum3B131898B0F57FED
Keywords
- Technical term