A0A419FDC6 · A0A419FDC6_UNCZI

Function

function

Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site65Zn2+ 1 (UniProtKB | ChEBI)
Binding site67Zn2+ 1 (UniProtKB | ChEBI)
Binding site67-69substrate
Binding site99substrate
Binding site156Zn2+ 1 (UniProtKB | ChEBI)
Binding site156Zn2+ 2 (UniProtKB | ChEBI)
Binding site183Zn2+ 2 (UniProtKB | ChEBI)
Binding site236Zn2+ 2 (UniProtKB | ChEBI)
Active site309
Binding site309Zn2+ 1 (UniProtKB | ChEBI)
Binding site313substrate
Binding site327-328substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionallantoinase activity
Molecular Functiondihydroorotase activity
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular FunctionRNA binding
Molecular Functiontranslation elongation factor activity
Molecular Functionzinc ion binding
Biological Process'de novo' UMP biosynthetic process
Biological Processpurine nucleobase catabolic process
Biological Processselenocysteine incorporation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydroorotase
  • EC number
  • Short names
    DHOase

Gene names

    • Name
      selB
    • Synonyms
      pyrC
    • ORF names
      C4524_06230

Organism names

Accessions

  • Primary accession
    A0A419FDC6

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain419-588Tr-type G

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,061
  • Mass (Da)
    115,062
  • Last updated
    2019-05-08 v1
  • Checksum
    CF4C1EECD2C03165
MEAIKLPQTLWLKNARLLDPALDLDIRGDLRVEDGRVAAVGKASGGGASWDLQGAVVCPGFFDLHVHLREPGNEEAETIRSGQEAAAAGGFTAVAAMPNTTPALDHAGLVRWVVDYASTFPVAVYPVGAITKGRQGEELTEMVELRQAGAIAFSDDGSHVKSAEIMRRALEYSLLTGAPIITHAEEGGLSLGGAMHEGEWSTRLGLPGIPRLSEDIATVRDLMLAQYTGGRLHLAHVSTAGALEALQSFRTRGTRATGEATPHHLLLTDAAVAGYDTSTKMKPPLREEADRLALWEGLKQGVVTAVATDHAPHTWDDKEVTYDEAAFGALGLETALGLIWDRGVRAGLISPAEMIRLFCHGPRAVVDAPQPALQAEIPAELTIFHPDEEWTVETERFYSKAKNSPFAGWNRASKAMTAPRHMIAATAGHIDHGKTALVRALTGMETDRLEEEKRRGITIELGFAFLGRNVTLIDVPGHERFIKTMVAGVSTVDLGLLVVAADDGVMPQTREHLDILRLLGVPRLFAVLTKVDGLEPDWVGMIEEEVRELLPDEYRAATPFFRCDALSGEGVEALKTALLALADRLPPRRDRGVFRLPVDRVFSVKGYGTVVTGTILGGSVRAGDRLRVMPGVREVRVRGMQSHGVDRDSLGAGDRAALNLGGLEAGDLGRGDWLCEPEAVLPSERLDVALDVLEHAPPVKHRDRVHFHLGTGEILGRILLLRDEAALPGRRTVAQVRLEGPVAAARGDRFVIRRYSPPETLGGGEVLDPLPEERRRGDLPETSELAALASAADLEALAWKVRRMGTAGLPWDQARAFAGLPVAGLDGVVGQLEARGEILRLGSAAGMILFSREALERAREAIRTRLDDFHHRFPDQLGLTRARLLSDLAAVFPPALLERALDDRASGEPVLEKGVLRRAGHRIHLEADTAARADRVETLLREAGLAPPGLEALARQAGLTEADLVRLLGVMQAQDRVVRQEDFYWAAEAVDRAWEIVRRELAAGAGRTTSDLREALGCPRRHAVALLEHFDRLGRTQRREDFRFPGPEFAASASHIEAKNP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QZKQ01000053
EMBL· GenBank· DDBJ
RJP78668.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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