A0A411PII0 · A0A411PII0_9GAMM
- ProteinProtein translocase subunit SecA
- GenesecA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids906 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
Catalytic activity
Cofactor
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cell envelope Sec protein transport complex | |
Cellular Component | cytosol | |
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Biological Process | intracellular protein transmembrane transport | |
Biological Process | protein import | |
Biological Process | protein targeting | |
Biological Process | protein transport by the Sec complex |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein translocase subunit SecA
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Alteromonadales > Shewanellaceae > Shewanella
Accessions
- Primary accessionA0A411PII0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Membrane ; Peripheral membrane protein
Note: Distribution is 50-50.
Keywords
- Cellular component
Interaction
Subunit
Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
Structure
Family & Domains
Features
Showing features for domain, coiled coil, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 3-619 | SecA family profile | ||||
Sequence: GKLLTKVFGSRNDRTLKSLGKVVKKINALEAEYEQYSDEQLKAKTAEFRERIGAGESLDAIMAEAFATVREASKRVFEMRHFDVQLLGGMVLDSNRIAEMRTGEGKTLTATLPAYLNGLTGKGVHIITVNDYLARRDAENNRPLFEFLGLSVGINVAGLGQAEKKEAYGSDITYGTNNEFGFDYLRDNMAFSPQERVQRPLHYALIDEVDSILIDEARTPLIISGAAEDSSELYIKVNTLIPSLIRQDKEDTEDYVGEGDFTVDEKAKQVHLTERGQEKVEALLVEREMLSEDDSLYSASNISLLHHVYAALRAHTLFERDVDYIIQDGDVVIVDEHTGRTMPGRRWSEGLHQAVEAKEGVNIQNENQTLASITFQNYFRQYEKLAGMTGTADTEAFEFQHIYGLDTVVVPTNRPMVRDDMADLVYLTAGEKYQAIIKDIQGCRERGQPVLVGTVSIEQSELLATLLKQAKIPHNVLNAKFHEKEADIVAQAGRLGAVTIATNMAGRGTDIVLGGNWNMEVAALQEPTDEQIAKIKADWQIRHDEVVAAGGLHILGTERHESRRIDNQLRGRAGRQGDAGSSRFYLSMEDSLMRIFASERVSGMMKKLGMEEGEAIE | ||||||
Coiled coil | 21-48 | |||||
Sequence: LGKVVKKINALEAEYEQYSDEQLKAKTA | ||||||
Domain | 89-247 | Helicase ATP-binding | ||||
Sequence: LGGMVLDSNRIAEMRTGEGKTLTATLPAYLNGLTGKGVHIITVNDYLARRDAENNRPLFEFLGLSVGINVAGLGQAEKKEAYGSDITYGTNNEFGFDYLRDNMAFSPQERVQRPLHYALIDEVDSILIDEARTPLIISGAAEDSSELYIKVNTLIPSLI | ||||||
Domain | 437-635 | Helicase C-terminal | ||||
Sequence: AIIKDIQGCRERGQPVLVGTVSIEQSELLATLLKQAKIPHNVLNAKFHEKEADIVAQAGRLGAVTIATNMAGRGTDIVLGGNWNMEVAALQEPTDEQIAKIKADWQIRHDEVVAAGGLHILGTERHESRRIDNQLRGRAGRQGDAGSSRFYLSMEDSLMRIFASERVSGMMKKLGMEEGEAIEHPWVSRAIENAQRKVE | ||||||
Region | 834-906 | Disordered | ||||
Sequence: QSDVDEMEQRRREEQEKIQRDYQHAAAQALAEGEDTVPQGPRTVVRDGQKVGRNDPCPCGSGKKYKQCHGKLS | ||||||
Compositional bias | 837-854 | Basic and acidic residues | ||||
Sequence: VDEMEQRRREEQEKIQRD |
Sequence similarities
Belongs to the SecA family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length906
- Mass (Da)102,650
- Last updated2019-05-08 v1
- Checksum329BF31D64C2BC2D
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 837-854 | Basic and acidic residues | ||||
Sequence: VDEMEQRRREEQEKIQRD |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP036200 EMBL· GenBank· DDBJ | QBF83355.1 EMBL· GenBank· DDBJ | Genomic DNA |