A0A411PII0 · A0A411PII0_9GAMM

  • Protein
    Protein translocase subunit SecA
  • Gene
    secA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

Catalytic activity

  • ATP + H2O + cellular proteinSide 1 = ADP + phosphate + cellular proteinSide 2.
    EC:7.4.2.8 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Features

Showing features for binding site.

1906100200300400500600700800900
TypeIDPosition(s)Description
Binding site87ATP (UniProtKB | ChEBI)
Binding site105-109ATP (UniProtKB | ChEBI)
Binding site512ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcell envelope Sec protein transport complex
Cellular Componentcytosol
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological Processintracellular protein transmembrane transport
Biological Processprotein import
Biological Processprotein targeting
Biological Processprotein transport by the Sec complex

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein translocase subunit SecA
  • EC number

Gene names

    • Name
      secA
    • ORF names
      EXU30_12050

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • D4-2
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Alteromonadales > Shewanellaceae > Shewanella

Accessions

  • Primary accession
    A0A411PII0

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein
Cytoplasm
Membrane
; Peripheral membrane protein
Note: Distribution is 50-50.

Keywords

Interaction

Subunit

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.

Family & Domains

Features

Showing features for domain, coiled coil, region, compositional bias.

TypeIDPosition(s)Description
Domain3-619SecA family profile
Coiled coil21-48
Domain89-247Helicase ATP-binding
Domain437-635Helicase C-terminal
Region834-906Disordered
Compositional bias837-854Basic and acidic residues

Sequence similarities

Belongs to the SecA family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    906
  • Mass (Da)
    102,650
  • Last updated
    2019-05-08 v1
  • Checksum
    329BF31D64C2BC2D
MLGKLLTKVFGSRNDRTLKSLGKVVKKINALEAEYEQYSDEQLKAKTAEFRERIGAGESLDAIMAEAFATVREASKRVFEMRHFDVQLLGGMVLDSNRIAEMRTGEGKTLTATLPAYLNGLTGKGVHIITVNDYLARRDAENNRPLFEFLGLSVGINVAGLGQAEKKEAYGSDITYGTNNEFGFDYLRDNMAFSPQERVQRPLHYALIDEVDSILIDEARTPLIISGAAEDSSELYIKVNTLIPSLIRQDKEDTEDYVGEGDFTVDEKAKQVHLTERGQEKVEALLVEREMLSEDDSLYSASNISLLHHVYAALRAHTLFERDVDYIIQDGDVVIVDEHTGRTMPGRRWSEGLHQAVEAKEGVNIQNENQTLASITFQNYFRQYEKLAGMTGTADTEAFEFQHIYGLDTVVVPTNRPMVRDDMADLVYLTAGEKYQAIIKDIQGCRERGQPVLVGTVSIEQSELLATLLKQAKIPHNVLNAKFHEKEADIVAQAGRLGAVTIATNMAGRGTDIVLGGNWNMEVAALQEPTDEQIAKIKADWQIRHDEVVAAGGLHILGTERHESRRIDNQLRGRAGRQGDAGSSRFYLSMEDSLMRIFASERVSGMMKKLGMEEGEAIEHPWVSRAIENAQRKVEQRNFDIRKQLLEYDDVANDQRQVVYSQRNELMDTDSIEDTIRNIEQDVITSTIDQYIPPQSVEELWDVEGLEQRLQNEFNIALPVKDWLEKEDDLHEETLRERILEAWTTSYKAKEEMVGEQVLRQFEKAVMLQTLDGLWKEHLSAMDHLRQGIHLRGYAQKNPKQEYKRESFELFQQMLESLKHDVISILSKVQVQAQSDVDEMEQRRREEQEKIQRDYQHAAAQALAEGEDTVPQGPRTVVRDGQKVGRNDPCPCGSGKKYKQCHGKLS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias837-854Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP036200
EMBL· GenBank· DDBJ
QBF83355.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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