A0A411PDI0 · A0A411PDI0_9GAMM

  • Protein
    lactoylglutathione lyase
  • Gene
    gloA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Ni2+ (UniProtKB | Rhea| CHEBI:49786 )

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.

Pathway

Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site58Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site76Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Active site124Proton donor/acceptor
Binding site124Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionlactoylglutathione lyase activity
Molecular Functionmetal ion binding
Biological Processmethylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    lactoylglutathione lyase
  • EC number
  • Alternative names
    • Aldoketomutase
    • Glyoxalase I
    • Ketone-aldehyde mutase
    • Methylglyoxalase
    • S-D-lactoylglutathione methylglyoxal lyase

Gene names

    • Name
      gloA
    • ORF names
      EXU30_01740

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • D4-2
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Alteromonadales > Shewanellaceae > Shewanella

Accessions

  • Primary accession
    A0A411PDI0

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-128VOC

Sequence similarities

Belongs to the glyoxalase I family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    136
  • Mass (Da)
    14,689
  • Last updated
    2019-05-08 v1
  • Checksum
    55F858F389169C0D
MAQLLHTMLRVGNLEKSIEFYTKVMGMSLLRQSENTEYKYTLAFVGFGDESSGQAVIELTYNWGVEEYDLGSAFGHIAIGEEDIYARCKAIEAAGGKVTRAPGPVAGGKTEIAFVEDPDGYKIELIQQASATAALG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP036200
EMBL· GenBank· DDBJ
QBF81558.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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