A0A411PDI0 · A0A411PDI0_9GAMM
- Proteinlactoylglutathione lyase
- GenegloA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids136 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- (R)-S-lactoylglutathione = methylglyoxal + glutathione
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.
Pathway
Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 58 | Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners | ||||
Sequence: E | ||||||
Binding site | 76 | Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners | ||||
Sequence: H | ||||||
Active site | 124 | Proton donor/acceptor | ||||
Sequence: E | ||||||
Binding site | 124 | Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | lactoylglutathione lyase activity | |
Molecular Function | metal ion binding | |
Biological Process | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namelactoylglutathione lyase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Alteromonadales > Shewanellaceae > Shewanella
Accessions
- Primary accessionA0A411PDI0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 3-128 | VOC | ||||
Sequence: QLLHTMLRVGNLEKSIEFYTKVMGMSLLRQSENTEYKYTLAFVGFGDESSGQAVIELTYNWGVEEYDLGSAFGHIAIGEEDIYARCKAIEAAGGKVTRAPGPVAGGKTEIAFVEDPDGYKIELIQQ |
Sequence similarities
Belongs to the glyoxalase I family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length136
- Mass (Da)14,689
- Last updated2019-05-08 v1
- Checksum55F858F389169C0D
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP036200 EMBL· GenBank· DDBJ | QBF81558.1 EMBL· GenBank· DDBJ | Genomic DNA |