A0A411PD08 · A0A411PD08_9GAMM

  • Protein
    Succinyl-diaminopimelate desuccinylase
  • Gene
    dapE
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Co2+ (UniProtKB | Rhea| CHEBI:48828 )

Note: Binds 2 Zn2+ or Co2+ ions per subunit.

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 3/3.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site69Zn2+ 1 (UniProtKB | ChEBI)
Active site71
Binding site102Zn2+ 2 (UniProtKB | ChEBI)
Binding site102Zn2+ 1 (UniProtKB | ChEBI)
Active site136Proton acceptor
Binding site137Zn2+ 2 (UniProtKB | ChEBI)
Binding site165Zn2+ 1 (UniProtKB | ChEBI)
Binding site351Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functioncobalt ion binding
Molecular Functionsuccinyl-diaminopimelate desuccinylase activity
Molecular Functionzinc ion binding
Biological Processdiaminopimelate biosynthetic process
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Succinyl-diaminopimelate desuccinylase
  • EC number
  • Short names
    SDAP desuccinylase
  • Alternative names
    • N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase

Gene names

    • Name
      dapE
    • ORF names
      EXU30_01040

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • D4-2
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Alteromonadales > Shewanellaceae > Shewanella

Accessions

  • Primary accession
    A0A411PD08

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain178-285Peptidase M20 dimerisation

Sequence similarities

Belongs to the peptidase M20A family. DapE subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    379
  • Mass (Da)
    41,277
  • Last updated
    2019-05-08 v1
  • Checksum
    E11611F351BA8170
MKQDSAVLALAKDLISRESITPLDEGCQELMAERLKALGFEIESMVFEDTTNMWARKGKGDPVFCFAGHTDVVPTGDINRWHTPPFTPTVIDDYLHGRGAADMKGSLAAMVIATERFIEKNPDHQGSIAFLITSDEEGPFINGTTRVIDTLEARNEKITWALVGEPSSTHKLGDVVKNGRRGSLTGNLVVKGVQGHVAYPHLADNPVHKAAPALAELAQMHWDHGNEFFPPTSFQIANINGGTGASNVIPGDLKVMFNFRYSTEVTAEELIKRVLNILDAHGLDYDIDWIFNGLPFLTGEGPLLDATKEAILEVTGYETDPQTSGGTSDGRFIAPTGAQVIELGPVNATIHKVNECVKVADLDVLALCYERILEKLLCK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP036200
EMBL· GenBank· DDBJ
QBF81436.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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