A0A411K9Y1 · A0A411K9Y1_ANDDA

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processoxidative phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COX1

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    A0A411K9Y1

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane45-66Helical
Transmembrane87-111Helical
Transmembrane131-154Helical
Transmembrane166-193Helical
Transmembrane213-239Helical
Transmembrane251-274Helical
Transmembrane286-308Helical
Transmembrane320-342Helical
Transmembrane362-383Helical
Transmembrane395-413Helical
Transmembrane433-456Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-495Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    499
  • Mass (Da)
    54,752
  • Last updated
    2019-05-08 v1
  • Checksum
    8DAB1FCDE79930CA
LYLVFGAXAGMVGTALSLLIRAELSQPGTLLGDDQIYNVIVTAHAFVMIFXXVMPIMXGGFGNWLVXXXXXXXDMAFXRMNNMSFWLLPPSFLLLLASSGIEAGAGTGWTVYPPLASNLAHAGASVDLTIFSLHLAGXSSILGAINFITTSINMXPPAMTQYQTPLFVWSVLITAILLLLSLPVLAAGITMLLTDRNLNTTFFDPSGGGDPVLYQHLXXXXXXXXXXXXXXXXXXXXXXXXXXYSAKKEPFGYMGMVWAMMSIGLLGFIVWAHHMFTVDLNVDTRAYFTSATMIIAIPTGVKVFSWLATMHGGSIKWDAAXXXXXXXXXXXTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYXXXMGAVFAIMGGFVHWFPLFSGYTLHAMWSKIHFGVMFLGVNLTFFPQHFLGLAGMPRRYSDYPDAYTLWNTVSSIGSLISMIAVVMIXFIXWEAFSAKREISTTDLSSTNVEWLXGCPPPHHTYEEPSYVQTRXN

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MK177462
EMBL· GenBank· DDBJ
QBC75080.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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