A0A411FV99 · A0A411FV99_GEOBU

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Castorimorpha > Geomyidae > Geomys

Accessions

  • Primary accession
    A0A411FV99

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-33Helical
Transmembrane53-79Helical
Transmembrane100-124Helical
Transmembrane144-167Helical
Transmembrane179-206Helical
Transmembrane239-257Helical
Transmembrane264-287Helical
Transmembrane299-321Helical
Transmembrane333-355Helical
Transmembrane375-396Helical
Transmembrane408-429Helical
Transmembrane449-469Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-510Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    510
  • Mass (Da)
    56,450
  • Last updated
    2019-05-08 v1
  • Checksum
    198656A0D9C4AF9B
RWLFSTNHKDIGTLYMIFGAWAGMVGTGLSILIRAELGQPGSLLGDDQIYNVVVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAITQYQTPLFVWSVMITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMLWALGFIFLFTIGGLTGIVLSNSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLFTGYTLNDTWAKIHFTIMFVGVNMTFFPQHFLGLAGMPRRYSDYPDAYTMWNTISSMGSFISLTAVILMVYMIWEALASKRLVKSVPLTATNLEWMHGCPPPFHTFEEPVFIKSP

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue510

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MH319037
EMBL· GenBank· DDBJ
QBA97392.1
EMBL· GenBank· DDBJ
Genomic DNA
MH319038
EMBL· GenBank· DDBJ
QBA97393.1
EMBL· GenBank· DDBJ
Genomic DNA
MH319068
EMBL· GenBank· DDBJ
QBA97423.1
EMBL· GenBank· DDBJ
Genomic DNA
MH319070
EMBL· GenBank· DDBJ
QBA97425.1
EMBL· GenBank· DDBJ
Genomic DNA
MH319078
EMBL· GenBank· DDBJ
QBA97433.1
EMBL· GenBank· DDBJ
Genomic DNA
MH319085
EMBL· GenBank· DDBJ
QBA97440.1
EMBL· GenBank· DDBJ
Genomic DNA
MH319099
EMBL· GenBank· DDBJ
QBA97454.1
EMBL· GenBank· DDBJ
Genomic DNA
MH319102
EMBL· GenBank· DDBJ
QBA97457.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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