A0A411FV97 · A0A411FV97_GEOKN

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Castorimorpha > Geomyidae > Geomys

Accessions

  • Primary accession
    A0A411FV97

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-33Helical
Transmembrane53-79Helical
Transmembrane100-124Helical
Transmembrane144-167Helical
Transmembrane179-206Helical
Transmembrane239-257Helical
Transmembrane264-287Helical
Transmembrane299-321Helical
Transmembrane333-355Helical
Transmembrane375-396Helical
Transmembrane408-429Helical
Transmembrane449-469Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-510Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    510
  • Mass (Da)
    56,418
  • Last updated
    2019-05-08 v1
  • Checksum
    F815450A810C9418
RWLFSTNHKDIGTLYMIFGAWAGMVGTGLSILIRAELGQPGSLLGDDQIYNVVVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAITQYQTPLFVWSVMITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMLWALGFIFLFTIGGLTGIVLSNSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLFTGYTLNDTWAKIHFTVMFVGVNMTFFPQHFLGLAGMPRRYSDYPDAYTMWNTISSMGSFISLTAVILMVYMIWEALASKRLVKSVPLTATNLEWLHGCPPPFHTFEEPVFIKSP

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue510

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MH319035
EMBL· GenBank· DDBJ
QBA97390.1
EMBL· GenBank· DDBJ
Genomic DNA
MH319045
EMBL· GenBank· DDBJ
QBA97400.1
EMBL· GenBank· DDBJ
Genomic DNA
MH319051
EMBL· GenBank· DDBJ
QBA97406.1
EMBL· GenBank· DDBJ
Genomic DNA
MH319052
EMBL· GenBank· DDBJ
QBA97407.1
EMBL· GenBank· DDBJ
Genomic DNA
MH319053
EMBL· GenBank· DDBJ
QBA97408.1
EMBL· GenBank· DDBJ
Genomic DNA
MH319055
EMBL· GenBank· DDBJ
QBA97410.1
EMBL· GenBank· DDBJ
Genomic DNA
MH319056
EMBL· GenBank· DDBJ
QBA97411.1
EMBL· GenBank· DDBJ
Genomic DNA
MH319057
EMBL· GenBank· DDBJ
QBA97412.1
EMBL· GenBank· DDBJ
Genomic DNA
MH319058
EMBL· GenBank· DDBJ
QBA97413.1
EMBL· GenBank· DDBJ
Genomic DNA
MH319060
EMBL· GenBank· DDBJ
QBA97415.1
EMBL· GenBank· DDBJ
Genomic DNA
MH319061
EMBL· GenBank· DDBJ
QBA97416.1
EMBL· GenBank· DDBJ
Genomic DNA
MH319063
EMBL· GenBank· DDBJ
QBA97418.1
EMBL· GenBank· DDBJ
Genomic DNA
MH319066
EMBL· GenBank· DDBJ
QBA97421.1
EMBL· GenBank· DDBJ
Genomic DNA
MH319067
EMBL· GenBank· DDBJ
QBA97422.1
EMBL· GenBank· DDBJ
Genomic DNA
MH319069
EMBL· GenBank· DDBJ
QBA97424.1
EMBL· GenBank· DDBJ
Genomic DNA
MH319071
EMBL· GenBank· DDBJ
QBA97426.1
EMBL· GenBank· DDBJ
Genomic DNA
MH319079
EMBL· GenBank· DDBJ
QBA97434.1
EMBL· GenBank· DDBJ
Genomic DNA
MH319080
EMBL· GenBank· DDBJ
QBA97435.1
EMBL· GenBank· DDBJ
Genomic DNA
MH319081
EMBL· GenBank· DDBJ
QBA97436.1
EMBL· GenBank· DDBJ
Genomic DNA
MH319082
EMBL· GenBank· DDBJ
QBA97437.1
EMBL· GenBank· DDBJ
Genomic DNA
MH319083
EMBL· GenBank· DDBJ
QBA97438.1
EMBL· GenBank· DDBJ
Genomic DNA
MH319084
EMBL· GenBank· DDBJ
QBA97439.1
EMBL· GenBank· DDBJ
Genomic DNA
MH319088
EMBL· GenBank· DDBJ
QBA97443.1
EMBL· GenBank· DDBJ
Genomic DNA
MH319089
EMBL· GenBank· DDBJ
QBA97444.1
EMBL· GenBank· DDBJ
Genomic DNA
MH319091
EMBL· GenBank· DDBJ
QBA97446.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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