A0A410RLK2 · A0A410RLK2_CORCK

Function

function

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 Mn2+ ion per subunit.

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site82substrate
Binding site210-212substrate
Binding site219Mn2+ (UniProtKB | ChEBI)
Binding site239Mn2+ (UniProtKB | ChEBI)
Binding site261substrate
Binding site262-267GTP (UniProtKB | ChEBI)
Active site263
Binding site288Mn2+ (UniProtKB | ChEBI)
Binding site378-380substrate
Binding site380GTP (UniProtKB | ChEBI)
Binding site411GTP (UniProtKB | ChEBI)
Binding site504-507GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionGTP binding
Molecular Functionkinase activity
Molecular Functionmanganese ion binding
Molecular Functionphosphoenolpyruvate carboxykinase (GTP) activity
Biological Processcellular response to glucose stimulus
Biological Processgluconeogenesis
Biological Processglycerol biosynthetic process from pyruvate
Biological Processphosphorylation
Biological Processpropionate catabolic process
Biological Processresponse to lipid
Biological Processresponse to starvation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoenolpyruvate carboxykinase [GTP]
  • EC number
  • Short names
    PEP carboxykinase
    ; PEPCK
  • Alternative names
    • GTP-dependent phosphoenolpyruvate carboxykinase
      (GTP-PEPCK
      )

Gene names

    • Name
      pckG
    • ORF names
      EJ065_1157

Organism names

Accessions

  • Primary accession
    A0A410RLK2

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain23-231Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Domain235-590Phosphoenolpyruvate carboxykinase C-terminal P-loop
Region361-387Disordered

Sequence similarities

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    597
  • Mass (Da)
    65,941
  • Last updated
    2019-05-08 v1
  • Checksum
    3864C85C4A0B2DBF
MASTQAAAATEQAPTKNPTLLAWVAKMAAMTQPDRIVWCDGSEAEKQRLTEQAVKDGTLIPLNPQKRPGCYLHRSNPNDVARVEHLTFICTPNKTDAGPTNNWMEPEAAYTKLSQLFEGCMKGRTMYVVPYAMGPLGGASTKIGVELTDSDYVVLNMRIMTRMGKAALDMLGDSDDFNRGLHSTGDVNPDRRYICHFPQDNTIWSFGSGYGGNVLLGKKCLALRIGSYLGREEGWLAEHMLILGVTSPKGETTYIAAAFPSACGKTNFAMMIPPKEYAGWKIETVGDDIAWMRPGPDGRLYAINPEAGYFGVVPGTNYKTNPNAMETISKDTLFTNVALTPDGDVWWEGKDGEVPEELTDWQGKPWKKGSTEKAAHPNSRFTAPMSNNPVLSGKANDPQGVPISAIIFGGRRSNTVPLVLQAFNWTHGVFLGATMGSETTAAATGKVGVVRRDPMAMLPFCGYHMGDYLQHWLDMQKSIPQLPKIFQVNWFRQDKNGKFIWPGFGDNMRVLEWIVNRVQGRVPTQETLLGWVPRQDQGLNLNGLDLPAEAIQEATSIKEDEWKSELKSQEVFFEQLGTKAPEALMLQRKLLIARLDG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP034669
EMBL· GenBank· DDBJ
QAT82761.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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