A0A401WDC0 · A0A401WDC0_STREY

Function

function

Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.
Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.

Features

Showing features for binding site, site, active site.

Type
IDPosition(s)Description
Binding site46-47D-ribulose 5-phosphate (UniProtKB | ChEBI)
Binding site47Mg2+ 1 (UniProtKB | ChEBI)
Binding site47Mg2+ 2 (UniProtKB | ChEBI)
Binding site51D-ribulose 5-phosphate (UniProtKB | ChEBI)
Site147Essential for DHBP synthase activity
Binding site161-165D-ribulose 5-phosphate (UniProtKB | ChEBI)
Binding site164Mg2+ 2 (UniProtKB | ChEBI)
Binding site185D-ribulose 5-phosphate (UniProtKB | ChEBI)
Site185Essential for DHBP synthase activity
Binding site273-277GTP (UniProtKB | ChEBI)
Binding site278Zn2+ (UniProtKB | ChEBI); catalytic
Binding site289Zn2+ (UniProtKB | ChEBI); catalytic
Binding site291Zn2+ (UniProtKB | ChEBI); catalytic
Binding site294GTP (UniProtKB | ChEBI)
Binding site317-319GTP (UniProtKB | ChEBI)
Binding site339GTP (UniProtKB | ChEBI)
Active site351Proton acceptor; for GTP cyclohydrolase activity
Active site353Nucleophile; for GTP cyclohydrolase activity
Binding site374GTP (UniProtKB | ChEBI)
Binding site379GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function3,4-dihydroxy-2-butanone-4-phosphate synthase activity
Molecular FunctionGTP binding
Molecular FunctionGTP cyclohydrolase II activity
Molecular Functionmagnesium ion binding
Molecular Functionmanganese ion binding
Molecular Functionzinc ion binding
Biological Processriboflavin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Riboflavin biosynthesis protein RibBA

Including 2 domains:

  • Recommended name
    3,4-dihydroxy-2-butanone 4-phosphate synthase
  • EC number
  • Short names
    DHBP synthase
  • Recommended name
    GTP cyclohydrolase-2
  • EC number
  • Alternative names
    • GTP cyclohydrolase II

Gene names

    • Name
      ribBA
    • ORF names
      GKJPGBOP_07036

Organism names

Accessions

  • Primary accession
    A0A401WDC0

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-222DHBP synthase
Region223-433GTP cyclohydrolase II
Domain229-394GTP cyclohydrolase II

Sequence similarities

In the C-terminal section; belongs to the GTP cyclohydrolase II family.
In the N-terminal section; belongs to the DHBP synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    433
  • Mass (Da)
    47,039
  • Last updated
    2019-05-08 v1
  • MD5 Checksum
    525D3251CEAEB25E5E97A9DE04A63135
MTALQSWYDPEGAVERDAVLALDPVEQAVADIAAGRPVVVVDDENRENEGDLIVAAERVTPEILAFMMSECRGLICAPMEGAELDRLALPQMVEHNTESMRTAFTVSVDATPAHGVSTGISAADRATTLRLLASGEATPADFVRPGHIFPLRAREGGVLARNGHTEAGVDLARLAGLRPAAAIVEIAGEDGTMLRLPELVPFARKHGLSIISIEDLIAYRRSSEPTVRREAETRLPTRHGEFTAYGYRSTVDGVEHIALVAGEIGDGEDILVRVHSECLTGDIFHSLRCDCGPQLEESLRRVQEAGRGVVIYLRGHEGRGIGLLSKLRAYELQERGRDTLDANLELGLPADARDYGAGAQVLADLGVRSLRLMTNNPEKTEALVRHGLKVLGREPMPVQAGEHNLRYLRTKRDRMGHDLPWLDADRASACGNQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BHZD01000001
EMBL· GenBank· DDBJ
GCD47270.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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