A0A401RLL6 · A0A401RLL6_CHIPU

Function

function

Multifunctional aminotransferase with a broad substrate specifcity. Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor. Catalyzes metabolism of not L- but the D-isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3-oxopropanoate and alanine. Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3-oxopropanoate. Can metabolize NG-monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  • (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine
    This reaction proceeds in the forward direction.
    EC:2.6.1.40 (UniProtKB | ENZYME | Rhea)
  • 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
    EC:2.6.1.44 (UniProtKB | ENZYME | Rhea)
  • N(omega),N(omega)-dimethyl-L-arginine + 2-oxobutanoate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + (2S)-2-aminobutanoate
  • 2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = L-2-aminohexanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate
  • 2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate
  • 3-oxopropanoate + L-alanine = beta-alanine + pyruvate
    This reaction proceeds in the backward direction.
    EC:2.6.1.18 (UniProtKB | ENZYME | Rhea)
  • oxaloacetate + L-alanine = L-aspartate + pyruvate
  • L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  • N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
  • N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate
  • N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
  • N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine
  • L-ornithine + glyoxylate = 5-amino-2-oxopentanoate + glycine
  • N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
  • N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine
  • N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

GO annotations

AspectTerm
Cellular Componentmitochondrion
Molecular Functionalanine-glyoxylate transaminase activity
Molecular Functionpyridoxal phosphate binding
Biological Processglyoxylate catabolic process
Biological ProcessL-alanine catabolic process, by transamination

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Alanine--glyoxylate aminotransferase 2, mitochondrial
  • EC number
  • Alternative names
    • (R)-3-amino-2-methylpropionate--pyruvate transaminase
    • Beta-ALAAT II
    • Beta-alanine-pyruvate aminotransferase
    • D-3-aminoisobutyrate-pyruvate aminotransferase
    • D-AIBAT
    • D-beta-aminoisobutyrate-pyruvate aminotransferase

Gene names

    • ORF names
      chiPu_0022165

Organism names

Accessions

  • Primary accession
    A0A401RLL6

Proteomes

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    91
  • Mass (Da)
    9,625
  • Last updated
    2019-05-08 v1
  • Checksum
    F325653A9FD0D6EC
MGRGLGPLGWCRTGGVNGTVQYPKGFLKEVAEIIRERGGLYISDEVQTGFGRLGSHYWGFQSHGVVPDIVTMAKGIGNGFPMGAVVTTPGE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BEZZ01006208
EMBL· GenBank· DDBJ
GCC19028.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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