A0A401P7R7 · A0A401P7R7_SCYTO
- ProteinHepatic triacylglycerol lipase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids495 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H+This reaction proceeds in the forward direction.
- 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H+This reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H+This reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H+This reaction proceeds in the forward direction.
- 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = H+ + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholineThis reaction proceeds in the forward direction.
- 1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H+This reaction proceeds in the forward direction.
- 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + H+ + sn-glycero-3-phospho-L-serineThis reaction proceeds in the forward direction.
- 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H+ + hexadecanoate + sn-glycerol 3-phosphocholineThis reaction proceeds in the forward direction.
Features
Showing features for active site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | high-density lipoprotein particle | |
Molecular Function | 1-acyl-2-lysophosphatidylserine acylhydrolase activity | |
Molecular Function | apolipoprotein binding | |
Molecular Function | heparin binding | |
Molecular Function | lipoprotein lipase activity | |
Molecular Function | lysophospholipase activity | |
Molecular Function | metal ion binding | |
Molecular Function | phosphatidylserine 1-acylhydrolase activity | |
Molecular Function | phospholipase A1 activity | |
Biological Process | fatty acid biosynthetic process | |
Biological Process | triglyceride catabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHepatic triacylglycerol lipase
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Chondrichthyes > Elasmobranchii > Galeomorphii > Galeoidea > Carcharhiniformes > Scyliorhinidae > Scyliorhinus
Accessions
- Primary accessionA0A401P7R7
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-21 | |||||
Sequence: MNNWAQISLLLFICAILKAQS | ||||||
Chain | PRO_5019277841 | 22-495 | Hepatic triacylglycerol lipase | |||
Sequence: ARTTRKDDTSVGRRKAQAESIKYCLFKGPSPNKEICCFTPNKAVTLETCGFNTSHPLVAIVHGWTLDGMYESWIWKMAAALKVRRKNINVLVIDWLTLAHQHYPIAVKNTRIVGQEIANLLDWLEEFFGFPKGKVHLIGYSLGAHVSGFAGNYITGTNRIGRITGLDPAGPLFEGMSSTERLSPDDANFVDAVHTFTQEHIGLSVGINQPVAHYDFYPNGGTIQPGCHLKHMYSHIAQYGILGITETVKCAHERSVHLFIDSLLNEDKQIVGYWCNDLSTFNKGTCLSCRKNRCNTLGYNIKKVRTQRSKKMYFKTRANMPYKVYHYQFKIRFINHMEHNILEPSLTVSLFGTEGDAENLPIKLVESITTNKTYSFLIHTDVNIGDLMLLKFKWENPVAWTNLWKTVQTYFQWGQNHLNPELIVRKIRIKAGETQHKVTFCPSNIDMHLQPAQEKKFVRCVSDRSRKRHRRISI |
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 346-481 | PLAT | ||||
Sequence: YHYQFKIRFINHMEHNILEPSLTVSLFGTEGDAENLPIKLVESITTNKTYSFLIHTDVNIGDLMLLKFKWENPVAWTNLWKTVQTYFQWGQNHLNPELIVRKIRIKAGETQHKVTFCPSNIDMHLQPAQEKKFVRC |
Sequence similarities
Belongs to the AB hydrolase superfamily. Lipase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length495
- Mass (Da)56,577
- Last updated2019-05-08 v1
- Checksum9847B8DB112D3AC5
Keywords
- Technical term