A0A401NYC7 · A0A401NYC7_SCYTO
- ProteinAprataxin
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids368 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH2) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity. Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA).
Catalytic activity
- a 3'-end 2'-deoxyribonucleotide-3'-diphospho-5'-guanosine-DNA + H2O = a 3'-end 2'-deoxyribonucleotide 3'-phosphate-DNA + GMP + 2 H+
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleolus | |
Cellular Component | nucleoplasm | |
Molecular Function | DNA 5'-adenosine monophosphate hydrolase activity | |
Molecular Function | DNA-3'-diphospho-5'-guanosine diphosphatase | |
Molecular Function | double-stranded RNA binding | |
Molecular Function | metal ion binding | |
Molecular Function | mismatched DNA binding | |
Molecular Function | single-strand break-containing DNA binding | |
Molecular Function | single-stranded DNA binding | |
Biological Process | single strand break repair |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAprataxin
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Chondrichthyes > Elasmobranchii > Galeomorphii > Galeoidea > Carcharhiniformes > Scyliorhinidae > Scyliorhinus
Accessions
- Primary accessionA0A401NYC7
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain, motif.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 112-130 | Basic and acidic residues | |||
Region | 112-176 | Disordered | |||
Compositional bias | 144-167 | Basic and acidic residues | |||
Domain | 195-300 | HIT | |||
Motif | 285-289 | Histidine triad motif | |||
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusFragment
- Length368
- Mass (Da)42,403
- Last updated2019-05-08 v1
- Checksum8256583F48DD80A1
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Compositional bias | 112-130 | Basic and acidic residues | |||
Compositional bias | 144-167 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BFAA01006936 EMBL· GenBank· DDBJ | GCB65888.1 EMBL· GenBank· DDBJ | Genomic DNA |