A0A401NYC7 · A0A401NYC7_SCYTO

Function

function

DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH2) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity. Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentnucleolus
Cellular Componentnucleoplasm
Molecular FunctionDNA 5'-adenosine monophosphate hydrolase activity
Molecular FunctionDNA-3'-diphospho-5'-guanosine diphosphatase
Molecular Functiondouble-stranded RNA binding
Molecular Functionmetal ion binding
Molecular Functionmismatched DNA binding
Molecular Functionsingle-strand break-containing DNA binding
Molecular Functionsingle-stranded DNA binding
Biological Processsingle strand break repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aprataxin
  • EC number
  • Alternative names
    • Forkhead-associated domain histidine triad-like protein

Gene names

    • ORF names
      scyTo_0013517

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Chondrichthyes > Elasmobranchii > Galeomorphii > Galeoidea > Carcharhiniformes > Scyliorhinidae > Scyliorhinus

Accessions

  • Primary accession
    A0A401NYC7

Proteomes

Subcellular Location

Keywords

  • Cellular component

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for compositional bias, region, domain, motif.

Type
IDPosition(s)Description
Compositional bias112-130Basic and acidic residues
Region112-176Disordered
Compositional bias144-167Basic and acidic residues
Domain195-300HIT
Motif285-289Histidine triad motif

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    368
  • Mass (Da)
    42,403
  • Last updated
    2019-05-08 v1
  • Checksum
    8256583F48DD80A1
AVRLQQPCCSMMRVCWLVSKDGRHQPIRLAHSVCVLIGRSPETQITDKKCSRHQVQLKADYNKGYVLVKQLGINPSYVNSEDLGRDQEVKLMPGQILHVVNRQYPYTIQFEGETSEKERLPPKRPHKEISPDSSANTLNKYLKAKDSNPREQHTFNTKPKEKNQGGHTGEDSSNSMTRINSAEACGRNDFQGMWSQGLKVSMQDPKLQVYKDDTVVVIRDKYPKARFHWLVLPWESIANLRAVKRDHLTLLQHMHQVGQKLVRECLDSDTLKFRLGYHAIPSMSHVHLHVISQDFDSPCLKNKKHWNSFNTDYFLESEDVMKMVEQDGKVTVKDGMAELLKRPLVCHVCQQQQSTIPQLKDHLKKHLP

Features

Showing features for non-terminal residue, compositional bias.

Type
IDPosition(s)Description
Non-terminal residue1
Compositional bias112-130Basic and acidic residues
Compositional bias144-167Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BFAA01006936
EMBL· GenBank· DDBJ
GCB65888.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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